lysophosphatidic acid


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Related to lysophosphatidic acid: lysophosphatidylcholine

ly·so·phos·pha·tid·ic ac·id

(lī'sō-fos'fă-tid'ik as'id),
A phosphatidic acid in which only one of the two hydroxyl groups of the glycerophosphate is esterified; most commonly, when carbon-1 of the glycerol moiety is esterified (for example, 1-acylglycerol-3-phosphate).

lysophosphatidic acid

Abbreviation: LPA
C21H41O7P, an acid purified from the ascitic fluid of patients with ovarian cancer. LPA stimulates the growth of ovarian cancer and may be a useful screening test for the disease.
CAS # 22002-87-5
See also: acid
References in periodicals archive ?
Increased production of bioactive lysophosphatidic acid by serum lysophospholipase D in human pregnancy.
LPA(4)/ GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation.
lysophosphatidic acid and lysophosphatidylcholine (LPC), [1] or the group of lysosphingolipids, e.
Catena's lead, VPC51299, antagonizes a subset of G-protein coupled receptors specific for lysophosphatidic acid (LPA), chemical in the body that promotes ovarian cancer tumor growth, and has been strongly implicated in organ fibrosis.
Lpathomab is a novel antibody targeting Lysophosphatidic Acid, or LPA, a bioactive lipid that has been characterized in the scientific literature as playing a key role in nerve injury and neuropathic pain.
of Massachusetts General Hospital, Harvard Medical School, will present a preclinical proof-of-concept study which demonstrates that the bioactive lipid lysophosphatidic acid (LPA), through its high affinity LPA1 receptor, is an important mediator of fibrogenesis in the bleomycin mouse model of scleroderma.
Mills has made significant contributions to the understanding of ovarian cancer, including the identification of lysophosphatidic acid as a possible biomarker for early-stage ovarian cancer and a potential target for therapy.
Tager's laboratory published a seminal paper demonstrating that the lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.