Lynch, Henry T.

(redirected from Lynch syndrome I)


Henry T., U.S. oncologist, 1928–.
Lynch syndrome I - familial predisposition to colon cancer.
Lynch syndrome II - familial predisposition for other primary cancers in addition to the predisposition for colon cancer; site is often female reproductive organs.
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Lynch syndrome is an autosomal dominant disorder that causes colorectal cancer, endometrial cancer, and upper gastrointestinal tract cancers among others.
Lynch syndrome is a hereditary autosomal dominant disorder characterized by considerably increased risks of colonic and extracolonic tumors and earlier age of onset.
"Given that Lynch syndrome is not rare in the general population, this finding has the potential to impact tens of thousands of people in the U.S."
Lynch syndrome is now well established as an inherited, autosomal dominant predisposition to CRC, and certain extracolonic cancers are derived from defective DNA mismatch repair (MMR) genes, which are a system for maintaining genome integrity.
Lynch Syndrome is the most common cause of inherited colorectal cancer (CRC), estimated to account for 2-5% of all CRC cases [1].
The risk for colorectal cancer among persons with Lynch syndrome is substantially higher than that of the general population (Table 1) (9).
Lynch Syndrome is estimated to cause 1,000 cases of bowel cancer each year, yet fewer than five per cent of people with the condition have been identified.
"Additionally, as Lynch syndrome is a genetic condition, it can have implications for other family members who may be at risk of developing bowel cancer so family members should also be tested to identify any others with the condition."
Lynch syndrome is a rare hereditary condition caused by a gene fault which increases the risk of several bowel cancer.
Lynch syndrome is the commoner of the two, accounting for 1-3% of all persons developing CRC, while FAP accounts for fewer than 1%.