LTBR

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LTBR

A gene on chromosome 12p13 that encodes lymphotoxin beta receptor, which belongs to the tumour-necrosis-factor-receptor superfamily and is expressed on the surface of most cell types (e.g., epithelial and myeloid lineages), but not on T or B cells. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta) and, with its ligand, plays a role in the development and organisation of lymphoid tissue and transformed cells. LTBR activation can trigger apoptosis; it associates with TRAF3, TRAF4 and TRAF5.
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Lymphotoxin beta receptor (LT[beta]R), a member of the tumor necrosis factor receptor superfamily, was reported to be associated with chronic inflammation diseases such as viral encephalitis [33], hepatitis B [34], IgA nephropathy [35], lymphoblastic leukemia [36], and type 1 diabetes [37] and plays a critical role in immune response and initiation of inflammation.
Park et al., "Association between lymphotoxin beta receptor gene polymorphisms and IgA nephropathy in Korean children," Immunological Investigations, vol.
Abbreviations AST: Aspartate transaminase DC: Dendritic cell ECM: Experimental cerebral malaria GBP: Guanylate-binding protein GTPBP1: GTP-binding protein 1 iNOS: Induced nitric oxide synthase IRG: Immunity-related gene 1 LDH: Lactate dehydrogenase LN: Lymph node LT: Lymphotoxin LT[beta]R: Lymphotoxin beta receptor mGBP: Murine guanylate-binding protein p.i.: Post infection TNFR: TNF receptor WT: Wild type.
Pfeffer, "The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues," Immunity, vol.
A trial with the novel agent baminercept, a lymphotoxin beta receptor fusion protein.
Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I function.