Rye Staging System

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Rye Staging System

A system for staging Hodgkin's disease delineated in 1966, which divided it into 4 distinct clinicopathological categories, based on data provided by the then popular method of lymphangiography. Cf Ann Arbor classification, Cotswolds classification.
Rye Classification–Hodgkin's disease
Lymphocytic predominant 10% of cases, more common in young adult ♂, usually early/low-stage disease without 'B' symptoms, 5-year survival: 90%
Nodular sclerosing 40%; more common in young adult ♀, usually early and low-stage disease with or without 'B' symptoms, 5-year survival: 70%
Mixed cellularity 40%; more common in young adult ♂, often stage II-III disease with or without 'B' symptoms, 5-year survival: 50%
Lymphocyte-depleted 10%; more common in older adult ?, usually stage III-IV disease with or without 'B' symptoms, 5-year survival, 30%
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Immunophenotypically, NLPHL is distinguished by the presence of large neoplastic cells (lymphocytic predominant cells) in a nodular distribution, with scattered nonneoplastic small B cells and T cells and the presence of a meshwork of dendritic follicular cells.
There are multiple causes of lymphocytic predominant pleural effusion other than TB such as malignancy and connective tissue diseases.
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A lymphocytic predominant pleocytosis was seen in 67.7% of initial LPs, and PMN cells predominated in 32.3%.
The most often reported is the epithelial membrane antigen (EMA), which is expressed in Hodgkin disease, mainly nodular lymphocytic predominant Hodgkin disease type (12) and plasma cell neoplasms.
The anterior mediastinal mass was diagnosed as thymoma, lymphocytic predominant type.

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