Rye Staging System

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Rye Staging System

A system for staging Hodgkin's disease delineated in 1966, which divided it into 4 distinct clinicopathological categories, based on data provided by the then popular method of lymphangiography. Cf Ann Arbor classification, Cotswolds classification.
Rye Classification–Hodgkin's disease
Lymphocytic predominant 10% of cases, more common in young adult ♂, usually early/low-stage disease without 'B' symptoms, 5-year survival: 90%
Nodular sclerosing 40%; more common in young adult ♀, usually early and low-stage disease with or without 'B' symptoms, 5-year survival: 70%
Mixed cellularity 40%; more common in young adult ♂, often stage II-III disease with or without 'B' symptoms, 5-year survival: 50%
Lymphocyte-depleted 10%; more common in older adult ?, usually stage III-IV disease with or without 'B' symptoms, 5-year survival, 30%
References in periodicals archive ?
There are multiple causes of lymphocytic predominant pleural effusion other than TB such as malignancy and connective tissue diseases.
Pleural Fluid Analysis: shows lymphocytic predominant exudative hemorrhagic pleural effusion with ADA 40u/lit.
The typical CSF change for TBM is a lymphocytic predominant pleocytosis, depressed glucose and elevated protein levels.
The most often reported is the epithelial membrane antigen (EMA), which is expressed in Hodgkin disease, mainly nodular lymphocytic predominant Hodgkin disease type (12) and plasma cell neoplasms.

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