LCK

(redirected from Lymphocyte-specific protein tyrosine kinase)

LCK

A gene on chromosome 1p34.3 that encodes a member of the Src family of non-receptor tyrosine kinases that is involved in the selection and maturation of developing T cells. LCK localises to the plasma membrane and pericentrosomal vesicles and binds to cell surface receptors, including CD4 and CD8, and other signalling molecules.
 
Molecular pathology
LCK translocation t(1;7)(p34;q34) with TCRB may be found in leukaemia.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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The following genes were studied: CD3[epsilon] molecule, epsilon (CD3-TCR complex) (CD3[epsilon]) (Hs99999153_m1), vav 1 guanine nucleotide exchange factor (VAV1) (Hs00232108_m1), zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70) (Hs_00896347), and lymphocyte-specific protein tyrosine kinase (LCK) (Hs00178427_m1).

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