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disease of the lymph nodes; called also adenopathy.
angioimmunoblastic lymphadenopathy (angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)) a systemic disorder resembling lymphoma characterized by fever, night sweats, weight loss, generalized lymphadenopathy, hepatosplenomegaly, macropapular rash, polyclonal hypergammaglobulinemia, and Coombs'-positive hemolytic anemia. It is considered to be a nonmalignant hyperimmune reaction to chronic antigenic stimulation; there is proliferation of B cells accompanied by profound deficiency of T cells. The disease follows a progressive but extremely variable course: some patients survive for a long period without chemotherapy; in other patients, overwhelming infections rapidly lead to death
dermatopathic lymphadenopathy regional lymph node enlargement associated with melanoderma and other dermatoses marked by chronic erythroderma.
immunoblastic lymphadenopathy angioimmunoblastic lymphadenopathy.
lymphadenopathy syndrome a condition occurring in immunocompromised individuals, characterized by unexplained lymphadenopathy for 3 or more months that involves extrainguinal sites, which on biopsy reveal nonspecific lymphoid hyperplasia. See also AIDS-related complex.


1. Any disease process affecting a lymph node or lymph nodes.
2. The appearance of enlarged lymph nodes found on a radiologic examination of any kind.
[lymphadeno- + G. pathos, suffering]


/lym·phad·e·nop·a·thy/ (-op´ah-the) disease of the lymph nodes.
angioimmunoblastic lymphadenopathy , angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) a systemic lymphoma-like disorder characterized by malaise, generalized lymphadenopathy, and constitutional symptoms; it is a nonmalignant hyperimmune reaction to chronic antigenic stimulation.
dermatopathic lymphadenopathy  regional lymph node enlargement associated with melanoderma and other dermatoses marked by chronic erythroderma.
immunoblastic lymphadenopathy  angioimmunoblastic l.


(lĭm-făd′n-ŏp′ə-thē, lĭm′fə-dn-)
n. pl. lymphadenopa·thies
An enlargement of the lymph nodes, usually associated with disease.


any disorder characterized by a localized or generalized enlargement of the lymph nodes or lymph vessels.


A generic term for lymph node enlargement of any aetiology, benign or malignant.

Lymphadenopathy, aetiology
• Viral—Infectious mononucleosis, CMV, HIV.
• Bacterial—Typhoid, TB, syphilis, Yersinia.
• Lymphoproliferative—especially lymphoma
• Metastases.

Lipid storage, Niemann-Pick, sphingomyelia.

Phenytoin, allopurinol, isoniazid.

Automimmune, rheumatoid arthritis, sarcoid, GVHD.

Benign hyperplasia, Langerhans cell histiocytosis.


Enlarged lymph nodes, follicular hypertrophy, swollen lymph glands Hematology Enlargement of lymph nodes of any etiology; the differential diagnostic considerations are multiple and divided into reactive patterns; benign lymphadenopathy is characterized by
1. Variability of the follicle–germinal center size;.
2. Lack of capsular or fat invasion;.
3. Mitotic activity confined to the germinal center;.
4. Cortical localization and inhomogeneous distribution of the follicles. See Angiography lymphadenopathy, Benign lymphadenopathy, Dermatopathic lymphadenopathy, Phenytoin lymphadenopathy, Shotty lymphadenopathy.


Any disease process affecting a lymph node or lymph nodes.
[G. lympha spring water +aden gland + G. pathos, suffering]


(lim″fad″ĕ-nop′ă-thē) [ lymph- + adenopathy]
Enlarge picture
CERVICAL LYMPHADENOPATHY: Squamous cell carcinoma of the neck
Enlargement of lymph nodes (LN), typically to greater than 1.5 cm. The increased size is caused by activation and proliferation of lymphocytes and phagocytic white blood cells within the node or by invasion of the node by tumor. Most often, lymphadenopathy is found in nodes involved in local, regional, or systemic infections; it results occasionally from cancers. Lymphadenopathy may also be found in an array of other, less common illnesses, including thyroiditis, thyrotoxicosis, autoimmune diseases (e.g., rheumatoid arthritis), sarcoidosis, and drug reactions (e.g., phenytoin). See: illustration

Enlarged LNs may be tender or not; tenderness often is present when lymph nodes swell rapidly (e.g., in response to infections, hypersensitivity reactions, or some fulminant lymphomas). Rock-hard, enlarged, and immobile LNs are typical of metastatic cancer, whereas rubbery LNs are found in lymphomas. LNs that do not resolve spontaneously within 4 to 6 weeks, or for which no obvious explanation exists, usually are sampled by biopsy or aspiration.

dermatopathic lymphadenopathy

Widespread lymphadenopathy secondary to various skin disorders.
See: table
CategoryExamplesLocationAge of patientTextureSizeAssociated signs or symptomsDiagnostic testsNecessity for biopsy or aspirate
Bacterial infectionStrep throat; cat scratch diseaseAngle of the jaw; axilla, neckChild or preteen; anyRelatively soft and tender; relatively soft and tender1 sq. cm; > 1 cmFever, sore throat, tonsillar exudate, malaise, headache, difficulty swallowing; may have fever, night sweats, weight lossCan be diagnosed clinically; antibody blood testsNo; not usually
GranulomaTuberculosis; sarcoidosisNeck, chest; hilum of the lung and other locationsAny; usually adultsRelatively soft and tender; rubbery> 1 cm; > 1 cm, sometimes massiveMay have fever, night sweats, weight loss, productive sputum; cough, shortness of breath, may have systemic illness, or be asymptomaticTuberculin (purified protein derivative), interferon blood test, sputum for acid-fast bacilli; blood for ACE levelsOccasionally; often
Metastatic cancerBreast cancerAxilla next to the breastAdultsStoneEspecially likely if > 2 cmLump in the breastMammography, ultrasound, other imaging techniquesYes
LymphomaHodgkin lymphomaChest, neck, axilla, groin, or all of these Young adultRubbery> 1 cmMay have fever, night sweats, weight loss, enlarged spleenRadiologic imagingYes
Viral infectionMononucleosis; HIV/AIDSHead and neck, spleen; generalizedYoung adult; any, but most often young adult or adultRubbery; firmAbout 1 cm; variableMay have fever, night sweats, weight loss; fever, night sweats, weight loss, or symptoms of opportunistic infectionTests for Epstein-Barr virus, heterophile antibody; antibody blood testsNo; not usually


Any disease process affecting a LYMPH NODE. Also known as lymphadenosis.

regional lymphadenopathy

tenderness, pain and swelling of regional lymph glands (e.g. popliteal or inguinal glands) indicative of proximal spread of distal infection, e.g. from the foot; usually associated with other signs of systemic infection, i.e. general malaise, pyrexia and fever and other constitutional symptoms

lymphadenopathy (lim·f·d·n·p·thē),

n a condition characterized by an abnormal increase in the size of the lymph nodes or lymph vessels.


An enlargement of a lymph gland. The preauricular lymph node located 1 cm in front of the external ear drains the orbital region and is sometimes involved with eyelid and conjunctival infection (e.g. adult inclusion conjunctivitis, follicular conjunctivitis). Syn. adenopathy (although strictly speaking this term refers to the enlargement of any gland).


1. Any disease process affecting lymph nodes.
2. The appearance of enlarged lymph nodes found on x-rays.
[G. lympha spring water + aden gland + G. pathos, suffering]


n a disease process that involves a lymph node or nodes.
lymphadenopathy, generalized,
n the involvement of all or several regionally separated groups of lymph nodes by a systemic disorder.
lymphadenopathy, persistent generalized (PGL),
n a swelling of the lymph nodes that is associated with HIV infection and AIDS. See acquired immunodeficiency syndrome (AIDS).
lymphadenopathy, regional,
n the involvement of nodes draining a specific region (e.g., submental nodes draining the middle of the lower lip, floor of the oral cavity, skin of the chin).


disease of the lymph nodes.

algal lymphadenopathy
enlargement and bright green coloration of lymph nodes caused by the presence of Prototheca spp.
hilar lymphadenopathy
enlargement of the tracheobronchial and pulmonary lymph nodes.

Patient discussion about lymphadenopathy

Q. my friend ate a bar of chocolate and now her left neck gland is swollen any ideas why? no other symptoms

A. it can be an infection -just like brandon said- or although this is rare, it can also be an allergic reaction.
if it is an infection, you can usually find such other infection symptoms like : fever, pain in that swollen area, increased white blood cells (in blood work test), etc.

if it is an allergy, usually it will fade away itself in couple of days, or you can just try to consume anti-allergic drugs, such as : loratadine and maybe combined with dexamethasone.

Good luck, and stay healthy always..

More discussions about lymphadenopathy
References in periodicals archive ?
According to Table 4, in our study, the lymph node enlargement is more common in male than in female.
Filariasis presenting as isolated lymph node enlargement in the neck is rare.
Bilateral pulmonary involvement, pulmonary involvement of all lobes, and lymph node enlargement were significantly more frequent CT findings in tuberculosis (TB) patients with diabetes mellitus (DM) compared with TB patients without DM.
Our study suggests that EBUS guided TBNA performed using a Wang 22-gauge needle is a useful and safe method in the diagnosis of HIV-negative adult patients with intrathoracic lymph nodes due to tuberculosis, which is responsible for most of the benign intrathoracic lymph node enlargements in our country [29].
3) Using the region of lymph node enlargement and its localization provides useful information about causes.
Since IPM usually presents as inguinal lymph node enlargement, the practicing cytologist may encounter IPM in fine needle aspiration.
Lymph node enlargement is the usual presentation; only about 20% of patients have B symptoms (i.
We encountered 15 patients with cervical soft-tissue tuberculosis out of 52 patients who had cervical lymph node enlargement or chronic abscess.
The variables analysed were age, sex, smoking index, clubbing, lymph node enlargement, fluid loculation, ESR, Mantoux, haemorrhagic pleural fluid and massive pleural effusion.
Tuberculosis is common in our country and it is not surprising that TB lymphadenopathy continues to be one of the commonest causes of chronic lymph node enlargement.
To the Editor: Lymph node enlargement is a common medical problem that is usually caused by bacterial, viral, fungal, or protozoal agents (1).
If lymph node enlargement persists despite antibiotics, yet an infectious or inflammatory cause is still suspected, further evaluation may include a PPD skin test and chest radiograph (1) (SOR: C, expert opinion).

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