Ly75

Ly75

A gene on chromosome 2q24 that encodes a C-type lectin-domain protein which acts as an endocytic receptor, directing captured antigens from the extracellular space to a specialised antigen-processing compartment. Ly75 also downregulates B-cell proliferation.
References in periodicals archive ?
In addition, AHR, CCL20, CD28, LY75, NFATC1, and NFKBIZ, which are newly identified candidate gene members, could regulate T cell responses to a certain extent [9].
In aging mice, at the mRNA level, several genes specific for T cells (CD3, CD8, T cell receptor, and LY75), antigen presentation ([beta]2-microglobulin and H2 molecules), T lymphocytes chemotaxis (CXCL9, CXCL10, CXCL11, and CCL5), and adhesion of leucocytes (ICAM-1) were overexpressed in the RPE/choroid complex and the retina [67, 68].