luliconazole

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luliconazole

(loo-li-kon-a-zole) ,

Luzu

(trade name)

Classification

Therapeutic: antifungals
Pharmacologic: azoles
Pregnancy Category: C

Indications

Topical treatment of interdigital tinea pedis, tinea cruris and tinea corporis.

Action

Inhibits an enzyme necessary for ergosterol synthesis, required for fungal cell membranes.
Antifungal action.

Therapeutic effects

Resolution of dermal fungal infection.
Active against Trichyphyton rubrum and Epidermpophyton floccosum.

Pharmacokinetics

Absorption: Small amounts are systemically absorbed.
Distribution: Unknown.
Protein Binding: >99%
Metabolism and Excretion: Unknown.
Half-life: unk

Time/action profile (improvement/resolution of infection)

ROUTEONSETPEAKDURATION
topunk3–4 wk†unknown
†Following initiation of treatment.

Contraindications/Precautions

Contraindicated in: None noted;
Use Cautiously in: Obstetric: Use in pregnancy only if potential benefit justifies any fetal risks; Lactation: Use cautiously in breast feeding women. Pediatric: Safe and effective use in children <18 yr not established.

Adverse Reactions/Side Effects

Dermatologic

  • application site reactions

Interactions

Drug-Drug interaction

May inhibit the activity of the CYP3A4 and CYP2C19 enzymes.

Route/Dosage

Topical (Adults) Interdigital tinea pedisApply to affected and surrounding areas once daily for two weeks; Tinea cruris and tinea corporisApply to affected and surrounding areas once daily for one week.

Availability

Topical cream: 1%

Nursing implications

Nursing assessment

  • Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.

Potential Nursing Diagnoses

Risk for impaired skin integrity (Indications)
Risk for infection (Indications)

Implementation

  • Consult health care professional for proper cleansing technique before applying medication.
  • Topical: For Interdigital tinea pedis: Apply thin layer to cover affected area and approximately 1 inch of immediate surrounding area completely daily for 2 wk.
    • For Tinea Cruris or Tinea Corporis: Apply thin layer to affected area and approximately 1 inch of immediate surrounding area daily for 1 wk.
    • Avoid the use of occlusive wrappings or dressings unless directed by health care professional. Wash hands after application.

Patient/Family Teaching

  • Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes and vagina.
  • Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
  • Advise patient to report increased skin irritation or lack of response to therapy to health care professional.
  • Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

  • Decrease in skin irritation and resolution of infection.
References in periodicals archive ?
His maternal home is Luzu village in Chamakanga, Vihiga County, but the family long relocated to Mawe Tatu in Kiungani, Kitale where they bought land and settled.Ms Beatrice Achitsa, his sister, described the death as tragic and a big loss to the family that was waiting for his arrival through Ethiopia on Sunday.
22 that the Food and Drug Administration has approved a supplemental New Drug Application to expand the use of Miconazole cream 1% (Luzu) to include the following indications: the topical treatment of patients aged 12 years and older with athlete's foot (interdigital tinea pedis) and jock itch (tinea cruris) and of patients aged 2 years and older with ringworm (tinea corporis) caused by the organisms Trichophyton rubrum and Epidermophyton floccosum.
The 20-year agreement with Walgreens takes effect in the first quarter of this year and will initially cover Valeant's dermatology products--including, most notably, Jublia for toenail fungus, Luzu, Solodyn for acne, Retin-A Micro Gel 0.08%, Onexton and Acanya Gel--and ophthalmology products including Besivance, Lotemax and Alrex.
A good option in diabetic patients is luliconazole (Luzu), which is active against Trichophyton rubrum--the most common causative organism--and has the advantage of simplicity: The regimen is once-daily treatment for 2 weeks, much shorter than for many other topical antifungals, Dr.
Luliconazole (Luzu), an azole anti-fungal, is a cream used for the treatment of tinea pedis, tinea cruris, and tinea corporis.
Doctor of Science (environmental engineering and landscape management), LUZU, 2005, Master of Science (material engineering), KTU, 1998.
Pariser discussed is luliconazole (Luzu), a prescription topical imidazole that is available as a 1% cream.
A good option in diabetic patients is luliconazole (Luzu), which is active against Trichophyton rubrum--the most common causative organism and has the advantage of simplicity: the regimen is once-daily treatment for 2 weeks, much shorter than for many other topical antifungals, Dr.