lupus anticoagulant

(redirected from Lupus Anticoagulant Test)

lu·pus an·ti·co·ag·u·lant (LA),

antiphospholipid antibody causing elevation in partial thromboplastin time; associated with venous and arterial thrombosis.
Farlex Partner Medical Dictionary © Farlex 2012

lupus anticoagulant

Lupus inhibitor Lab Medicine Any IgG or IgM class antibody that arise spontaneously in Pts with SLE; while LAs produce in vitro interference with phospholipid-dependent coagulation–eg, activated partial thromboplastin time–aPTT and kaolin clotting time assays in specimens from Pts with LE, they do not produce in vivo coagulopathy without other platelet or coagulation defects or drug-induced antibodies; LAs also occur in Pts with HIV, DVT, and other conditions Lab ↑ aPTT; LAs interfere with derivative assays for factors VIII, IX, XI, and XII. See Systemic lupus erythematosus. Cf Anticardiolipin antibodies.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

lu·pus an·ti·co·ag·u·lant

(lū'pŭs an'tē-kō-ag'yŭ-lănt)
Antiphospholipid antibody causing elevation in partial thromboplastin time; associated with venous and arterial thrombosis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

lupus anticoagulant

An antibody, or groups of antibodies, to negatively-charged phospholipids liable to be associated, paradoxically, with a tendency for blood to clot within the blood vessels. This may lead to deep vein thrombosis, arterial thrombosis with strokes and heart attacks and, in pregnant women, a strong tendency to fetal death and abortion. Some patients with LUPUS ERYTHEMATOSUS are known to have a positive result in tests for syphilis while not suffering from the disease. This effect is caused by the lupus anticoagulant. See also HUGHES' SYNDROME.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Patient Reference Test result interval Lupus anticoagulant test DRVVT, seconds 65.5 33-44 DRVVT mix, seconds 63.2 33-44 DRVVT confirmation, screen/ 1.70 0.00-1.20 confirmation Prothrombin time, seconds 12.6 10.0-14.0 APTT, seconds 33.5 22.8-35.0 Thrombin time, seconds 15.9 14.0-21.0 APS antibody test Anticardiolipin antibody Negative Negative Anti-[beta]2 glycoprotein I Negative Negative antibody Autoimmune antibody panel Antinuclear antibody (ANA) Positive Negative Anti-dsDNA Positive Negative Antihistones Positive Negative Anti-Sm Positive Negative Anti-snRNP70 Positive Negative SS-A(Ro) Positive Negative SS-B(La) Negative Negative Anti-Scl-70 Negative Negative Anticentromere Negative Negative Jo-1 Negative Negative Table 2.
Lupus anticoagulant test were done, which was prolonged by using a PTT and diluted Russell Viper Venom Time.
the ELISA is far more reproducible and, unlike the lupus anticoagulant test, can be reliably repeated on frozen or shipped specimens.