interstitial lung disease

(redirected from Lung fibrosis)

interstitial lung disease

Diffuse interstitial pulmonary fibrosis Pulmonology A group of disorders characterized by scarring of deep lung tissue, leading to SOB and loss of functional alveoli, limiting O2 exchange; ILD is more common in smokers Etiology Inorganic and organic dusts, gases, fumes, vapors, medications, radiation, and certain lung infections, hypersensitivity pneumonitis, coal worker's pneumoconiosis, silicosis, byssinosis, idiopathic
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Interstitial lung disease

About 180 diseases fall into this category of breathing disorders. Injury or foreign substances in the lungs (such as asbestos fibers) as well as infections, cancers, or inherited disorders may cause the diseases. They can lead to breathing or heart failure.
Mentioned in: Chest X Ray
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
(Reference Category; Lung Fibrosis and Male Gender) The patients with lung fibrosis on C-Xray have 3.72 (p= 0.042) and 5.22 times (p=0.013) higher chances of survival than, patients with bronchiectasis and destroyed lungs respectively.
Dublin GAA footballer and yoga instructor, Michael Darragh Macauley, is the face of the yoga exercise DVD produced by the Irish Lung Fibrosis Association.
I was referred to the respiratory service in 2008, started on other drugs and, after numerous tests, was diagnosed with lung fibrosis.
Interstitial lung fibrosis and rheumatic disorders in patients with hepatitis C virus infection.
Effects of L-carnitine and ginkgo biloba extract (EG b 761) in experimental bleomycin-induced lung fibrosis. Pharmacol Res.
It has demonstrated promising results in both pre-clinical efficacy models of inhibition of lung fibrosis as an orally delivered agent and a safety profile in GLP toxicology studies supporting its advancement into the clinic.
Failure to identify this group of patients could subsequently lead to progression of the disease and the development of secondary manifestations (22,23) such as laryngeal carcinoma, vocal cord granulomas and pulmonary aspiration and its multiplicity of complications such as bronchiectasis, lung fibrosis etc.
Germline mutations in the human TERT and TERC cause autosomal dominant dyskeratosis congenita, a rare hereditary disorder associated with premature death from aplastic anemia and pulmonary fibrosis.[18] TERT variants are the most frequently identified rare mutations related to pulmonary fibrosis, which were found in up to 15% of familial interstitial pneumonitis and in 1-3% sporadic cases.[8] This Ala716Thr variant of TERT was firstly reported in children with severe aplastic anemia and a family history of lung fibrosis.[19],[20] Thus, it was considered that within a single family carried this mutation, older generations were more likely to affected by adult-onset pulmonary fibrosis, whereas bone marrow failure was the first presentation in subsequent generations at a younger age.
The first in vivo evidence of drug efficacy was demonstrated in several experimental studies by Iyer and colleagues (17-20) by using bleomycin-induced lung fibrosis in a hamster model fed with a diet containing pirfenidone.