low-grade squamous intraepithelial lesion


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Related to low-grade squamous intraepithelial lesion: HPV, colposcopy

low-grade squamous intraepithelial lesion (LGSIL, LSIL),

term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities; these lesions include the cellular changes associated with human papillomavirus cytopathologic effect and mild dysplasia (cervical intraepithelial neoplasia grade 1).
See also: Bethesda system, reactive changes, ASCUS, atypical glandular cells of undetermined significance.

low-grade squamous intraepithelial lesion

Gynecologic cytology A lesion of the uterine cervix which is characterized by cells occurring singly or in sheets, nuclear abnormalities in cells with mature cytoplasm, bi- or multinucleation, well-defined optically clear perinuclear halo, distinct cell borders and others that translate into either HPV infection or mild dysplasia–CIN 1 of uterine cervix–a diagnosis made on biopsied tissue. Cf High-grade squamous intraepithelial lesion.

low-grade squa·mous in·tra·ep·i·the·li·al le·sion

(LGSIL, LSIL) (lō-grād skwā'mŭs in'tră-ep'i-thē'lē-ăl lē'zhŭn)
Term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities; these lesions include the cellular changes associated with human papillomavirus cytopathologic effects and mild dysplasia (cervical intraepithelial neoplasia grade 1).
See also: Bethesda system, reactive changes, ASCUS, atypical glandular cells of undetermined significance

low-grade squamous intraepithelial lesion

Abbreviation: LGSIL
A cytological abnormality found in Papanicolaou tests (Pap tests) where there are early mild changes in the epithelial cells covering the outside of the cervix. Causes include infection with human papillomavirus, cervical trauma, or postmenopausal changes. Risk factors include intercourse with multiple sex partners or a partner with multiple sex partners, unprotected sex at a young age, history of sexually transmitted disease, and tobacco use. About 60% of LGSIL will spontaneously resolve. If left untreated, a small number of women eventually develop cervical cancer.
See also: lesion
References in periodicals archive ?
Distribution of preceding Papanicolaou (Pap) test diagnoses divided into ''low-grade'' (atypical squamous cells of undetermined significance [ASC-US] and low-grade squamous intraepithelial lesion [LSIL]) and ''high-grade'' (low-grade squamous intraepithelial lesion, a highgrade squamous intraepithelial lesion cannot be ruled out [LSIL-H]; atypical squamous cells, a high-grade squamous intraepithelial lesion cannot be ruled out [ASC-H]; high-grade squamous intraepithelial lesions [HSIL]; atypical glandular cells [AGC]; adenocarcinoma in situ [AIS]; squamous cell carcinoma).
9,10) The aim of this report was to present the prevalence of HPV genotypes found in biopsies of women having low-grade squamous intraepithelial lesions (LSIL) in a population of 96 women at our colposcopy center.
Low-grade squamous intraepithelial lesions (LSIL) were seen in 57%, atypical squamous cells of undetermined significance (ASCUS) in 30%, high-grade squamous intraepithelial lesions (HSIL) in 7%, and atypical squamous cells in which HSIL cannot be excluded (ASC-H) in 5.
More than half of low-grade squamous intraepithelial lesions in adolescents have regressed at 12 months; 91% regress by 36 months (Lancet 2004;364:1678-83).
Low-grade squamous intraepithelial lesions were likely to regress in women older than 30 years who were not infected with types of human papillomavirus associated with a high risk for cervical cancer, a longitudinal study found.
In uninfected women, the mean time to progression from atypical squamous cells of undetermined significance (ASCUS) to low-grade squamous intraepithelial lesions (LSIL), or worse, is approximately 88 months; however; lesions infected with oncogenic HPV types show marked progression within 67 months.
The two types of samples retrieved had similar sensitivity and specificity for both atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesions (see box).
The majority of low-grade squamous intraepithelial lesions will regress spontaneously in adolescent females, so most treatment guidelines allow for the observation of these lesions through repeated cytology, said Dr.
Among three cases of low-grade squamous intraepithelial lesions (LSIL), one regressed spontaneously, and a biopsy in another found cervical intraepithelial neoplasia grade 3 (CIN3).
However, many were also using HPV testing for patients with Pap test results showing higher-grade lesions; 84% said they used it for atypical squamous cells results (cannot exclude high-grade squamous intraepithelial lesions); 61% said they used it for low-grade squamous intraepithelial lesions results; and 46% said they used it for high-grade squamous intraepithelial lesions results, Dr.
This included a group of t4- to 20-year-olds with low-grade squamous intraepithelial lesions (LSIL) and a second group of teens with high-grade squamous lesions (HSIL).
The study should take approximately 18 months to complete, and will evaluate the efficacy and safety of Interferon-alpha Cream in the treatment of women with low-grade squamous intraepithelial lesions ("LSIL") that are positive for human papilloma virus ("HPV") infection.

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