LDLR

(redirected from Low density lipoprotein receptor)
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LDLR

A gene on chromosome 19p13.2 that encodes a cell surface protein involved in receptor-mediated endocytosis of low-density lipoprotein (LDL), the major cholesterol-carrying lipoprotein of plasma, which it transports into cells by endocytosis. Internalisation of the receptor-ligand complex requires clustering into clathrin-coated pits.
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References in periodicals archive ?
Pretreatment with beta (2)-Glycoprotein I expressed in Pichia pastoris led to a strong inhibition of tissue factor and lectin-like oxidised low density lipoprotein receptor expression in a dose-dependent manner in macrophages.
Low density lipoprotein receptor activity in human monocytes-derived macrophages and its relation to atheromatous lesions.
Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route.
Parthasarathy et al., "Gene expression in macrophage-rich human atherosclerotic lesions: 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts," Journal of Clinical Investigation, vol.
Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells.
The low density lipoprotein receptor (LDLR) gene in familial hypercholesterolemia.
Universal primer quantitative fluorescent multiplex (UPQFM) PCR: a method to detect major and minor rearrangements of the low density lipoprotein receptor gene.
(19.) The low density lipoprotein receptor (LDLR) gene in familial hypercholesterolemia homepage.
The low density lipoprotein receptor prevents secretion of dense apoB100-containing lipoproteins from the liver.
New methods for rapid detection of low density lipoprotein receptor and apolipoprotein B gene mutation causing familial hypercholesterolemia.
Surface expression of low density lipoprotein receptor in EBV-transformed lymphocytes: characterization and use for studying familial hypercholesterolemia.

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