omega-3-acid ethyl esters

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omega-3-acid ethyl esters


Pharmacologic class: Combination ethyl esters of omega-3 fatty acids, principally eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)

Therapeutic class: Lipid-regulating agent

Pregnancy risk category C


Unclear. May include inhibition of acyl-CoA: 1,2-diacylglycerol acyltransferase, increased mitochondrial and peroxisomal β-oxidation in the liver, decreased lipogenesis in the liver, and increased plasma lipoprotein lipase activity; may reduce synthesis of triglycerides in the liver because EPA and DHA are poor substrates for the enzymes responsible for triglyceride synthesis, and EPA and DHA inhibit esterification of other fatty acids.


Capsules: 1 g

Indications and dosages

Adjunct to diet to reduce triglyceride levels in patients with severe (500 mg/dl or greater) hypertriglyceridemia

Adults: 4 g P.O. daily as a single 4-g dose or as 2-g dose P.O. b.i.d.


• Hypersensitivity to drug or its components


Use cautiously in:

• hepatic impairment

• hypersensitivity to fish or shellfish

• pregnant or breastfeeding patients

• children (safety and efficacy not established).


• Administer capsules whole with meals.

• Assess triglyceride levels carefully before starting therapy, and identify other causes (such as diabetes mellitus, hypothyroidism, or drugs) of high triglyceride levels; manage as appropriate.

• Ensure patient is on appropriate lipid-lowering diet before starting drug.

Adverse reactions

GI: vomiting, constipation, GI disorder, eructation, dyspepsia

Hepatic: increased liver enzyme levels

Skin: pruritus, rash

Other: taste perversion


Drug-drug. Anticoagulants, other drugs affecting coagulation (such as aspirin, NSAIDs): prolonged bleeding time

Drug-diagnostic tests. ALT, AST, LDL-C: increased levels

Patient monitoring

• Monitor hepatic function tests in patients with hepatic impairment.

• Monitor LDL-C and triglyceride levels periodically.

Patient teaching

• Tell patient to take capsules whole with meals and not to break open, crush, dissolve, or chew them.

• Instruct patient to tell prescriber if he's allergic to fish.

• Advise patient to maintain lipid-lowering diet.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

omega-3-acid ethyl esters

(ohme-ga three as-id eth-il es-ters) ,


(trade name)


Therapeutic: lipid lowering agents
Pharmacologic: fatty acids
Pregnancy Category: C


Hypertriglyceridemia (triglycerides ≥500 mmg/dL) in adults; used with specific diet.


Inhibits synthesis of triglycerides.

Therapeutic effects

Lowering of triglycerides.


Absorption: Well absorbed.
Distribution: Unknown.
Metabolism and Excretion: Incorporated into phospholipids.
Half-life: Unknown.

Time/action profile (lowering of triglycerides)

POunknown2 mounknown


Contraindicated in: Hypersensitivity.
Use Cautiously in: Allergy/hypersensitivity to fish; Obstetric / Lactation: Pregnancy or lactation; Pediatric: Safety not established.

Adverse Reactions/Side Effects


  • altered taste
  • eructation


  • rash


Drug-Drug interaction

May ↑ risk of bleeding with aspirin or warfarin.


Oral (Adults) 4 g/day; may be given as a single dose or 2 g twice daily.


Gelatin capsules (oil-filled): 1 g Cost: $196.69 / 100

Nursing implications

Nursing assessment

  • Obtain a diet history, especially with regard to fat consumption.
  • Lab Test Considerations: Monitor serum triglyceride levels prior to and periodically during therapy.
    • Monitor serum ALT periodically during therapy. May cause ↑ serum ALT without concurrent ↑ in AST levels.
    • Monitor serum LDL cholesterol levels periodically during therapy. May cause ↑ in serum LDL levels.

Potential Nursing Diagnoses

Noncompliance (Patient/Family Teaching)


  • Do not confuse Lovaza with lorazepam.
  • An appropriate lipid-lowering diet should be followed before therapy and should continue during therapy.
  • Oral: May be taken as a single 4-g dose or as 2 g twice daily. May be administered with meals. Swallow capsules whole; do not break or chew.

Patient/Family Teaching

  • Instruct patient to take medication as directed, not to skip doses or double up on missed doses. Take missed doses as soon as remembered, but if a day is missed, do not double doses the next day. Medication helps control but does not cure elevated serum triglyceride levels.
  • Advise patient that this medication should be used in conjunction with diet restrictions (fat, cholesterol, carbohydrates, alcohol), exercise, weight loss in overweight patients, and control of medical problems (such as diabetes mellitus and hypothyroidism) that may contribute to hypertriglyceridemia.
  • Emphasize the importance of follow-up exams to determine effectiveness.

Evaluation/Desired Outcomes

  • Lowering of serum triglyceride levels. Patients who do not have an adequate response after 2 mo of treatment should be withdrawn from therapy.
Drug Guide, © 2015 Farlex and Partners
References in periodicals archive ?
They were divided into four groups: one received vitamin D via 2,000 International Units (IUs) per day of cholecalciferol plus omega-3s (1 g per day of a prescription fish oil called Lovaza); one was given vitamin D plus placebo omega-3s; the third received omega-3s plus placebo vitamin D; and the fourth control group received placebos for both.
But which fish oil supplements provide the best quality and value--and how do they compare with prescription fish oils like Vascepa and Lovaza?
A: We used 1 gram--or 1,000 milligrams--a day of a very high quality FDA-approved medication called Omacor, which is known as Lovaza in the United States.
The FDA approved Lovaza in 2004, Vascepa in 2012, and Epanova and Omtryg in 2014.
Therefore, the studies examined found Lovaza [R] to be about 56% more effective than Vascepa[R] at triglyceride lowering when comparing median percent changes.
Prior to Akebia, Dr Shalwitz was medical director for Abbott Labs, where he received approval for two New Drug Applications (Lovaza and Neoprofen).
Its most selling products include Advair, Adovart, Flovent, Augmentin, Lovaza and Lamictal.
This review speaks solely of marine oil/fish oil supplements and the concentrated pharmaceuticals of concentrated DHA orEPA like Lovaza and Vascepa.
Under McGill's supervision, the first group received metformin alone; the second received metformin plus rosiglitazone (Avandia); and the third received metformin plus Lovaza, which is a kind of fish oil.
Prescription drugs include omega-3 fatty acids (Lovaza) and the fibrates gemfibrozil (Lopid) and clofibrate (Atromid-S).
1.6 No evidence 2015 Namenda Forest 1.4 Yes 2015 Lovaza GSK 1.3 No evidence 2015 Gleevec Novartis 4.7 No evidence 2016 Zetia MSD 2.3 No evidence 2016 Humira Abbott 6.5 Most likely Puerto Rico Source: Medco; Global Market Review and corporate websites * For 2011 and 2012 the table only present blockbusters that are partly produced in Ireland Table 2.