Lou Gehrig's disease

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amyotrophic lateral sclerosis

a progressive neurologic disease characterized by degeneration of cell bodies of the lower motor neurons in the gray matter of the anterior horns of the spinal cord, some brainstem motor neurons, and the pyramidal tracts. Called also Lou Gehrig's disease.

The disease presents in adulthood, usually between the ages of 40 and 70, and affects men two to three times more often than women. The initial symptom is weakness of skeletal muscles, especially in the limb. As the disease progresses the patient has difficulty swallowing and talking, with dyspnea as the accessory muscles of respiration are affected. Eventually muscles atrophy and the patient becomes a functional quadriplegic. Mentation is not affected, so that the patient remains alert and aware of functional loss and the inevitable outcome. Although there may be periods of remission, the disease usually progresses rapidly, with death in 2 to 5 years. The cause of ALS is not known and there is no cure. Treatment is intended to provide symptomatic relief, prevent complications, and maintain optimal function as long as possible.
Patient Care. For the most part, ALS patients are cared for at home and are hospitalized only for diagnosis, when severe dysphagia demands an esophagostomy or gastrostomy for feeding, or when medical treatment is necessary for acute respiratory problems.

Intervention is planned and implemented according to each patient's needs at specific times during the course of the illness. In general, the major problems encountered are those related to (1) dysphagia and the need to meet nutritional requirements and avoid aspiration, (2) dyspnea and maintenance of blood gases within normal range, (3) aphasia and impaired verbal communication, (4) weakness, impaired mobility, and activity intolerance, (5) constipation, (6) pain and discomfort due to muscle cramps, and (7) alteration in self-concept and body image.

The patient and family also will need assistance in managing home care, coping with the effects of the illness, and maintaining optimal functioning in the patient. Community health nurses and home health care professionals and paraprofessionals should be available to provide a variety of services including physical therapy, occupational therapy, social services, mental health care, and medical and nursing care.

A resource agency that can provide assistance and information to ALS patients and their families is the Amyotrophic Lateral Sclerosis Association, 21021 Ventura Blvd., Suite 321, Woodland Hills, CA 91364-2206, (800) 782–4747; http://www.alsa.org.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

Lou Gehrig's disease

(lo͞o′ gĕr′ĭgz)
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

amyotrophic lateral sclerosis

A chronic, progressive, degenerative, motor neurone disease, characterised by upper limb weakness, atrophy and focal neurologic signs.
Epidemiology Incidence 0.5–1.5/105, more common in men, usually >age 50; occurs randomly throughout the world with local clustering on the Kii Peninsula, Japan, and Guam, where it is associated with dementia, parkinsonism, and Alzheimer’s disease.
Clinical Loss of fine motor skills, triad of atrophic weakness of hands and forearms; leg spasticity; generalised hyperreflexia.
Management Possibly riluzole.
Terminal care Where allowed, one-fifth of all ALS patients choose to die by euthanasia.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Lou Gehrig's disease

A popular term in the USA for AMYOTROPHIC LATERAL SCLEROSIS. Lou Gherig (1904–41) was a baseball player for the Yankees of countrywide fame and popularity who, to the distress of all who knew him, began to develop signs of ALS in 1938.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Patient discussion about Lou Gehrig's disease

Q. What are the presenting signs of ALS? Are the upper or lower extremeties affected initialilly?

A. The most common presenting sign of ALS is asymmetric limb weakness, usually starting with the hands (problems with pinching, writing, holding things etc.) shoulders (lifting arms above head etc.) or legs (problems walking).

Other presenting signs may be problems with speaking or swallowing, although these are less common.

You may read more here:

Q. hola amigos como estan yo estranando al amor de mi via que es monica la amo mchoy la estrano bastante hola soy un tipo muy feliz ya encontre el amor de mi vida nos casamos en diciembre tenemos muchos suenos ,un camino muy largo que recorrer pienso entregarme por completo al amor y dedicarnos el uno para el hotro ,yon amo ami baby estoy muy enamorado ella lo sabe es mi baby te amo mi gatita bebe

A. ¿Cuál es la pregunta?

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References in periodicals archive ?
Lansbury joined the "Cure ALS Campaign" to honor her sister Isolde, who passed away from Lou Gehrig's disease in the late 1980s.
"Major League Baseball is making a huge difference in the fight against Lou Gehrig's disease through this July 4 effort," says Augie Nieto, founder and chief inspiration officer for MDA's Augie's Quest.
Washington, Feb 27 (ANI): Scientists have described a new human cell-derived model of myotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, which can offer new method of studying the disease and testing novel therapeutics.
No segment of society has escaped the wrath of ALS, commonly referred to as Lou Gehrig's Disease, and "ALS Across America" profiled this diversity.
French, Md., who predeceased her in 2005 and who also valiantly fought ALS for nine years; two brothers, Richard South of Pittsburgh, Pa.; and Furman South III, of Sewickley, Pa.; a sister, Helen Straub of Allison Park, Pa.; four grandchildren, Taylor, Lauren, Cameron and Lily; as well as many nieces and nephews and a dedicated group of loving caregivers who made it possible for her to remain in her own home, living with her family, despite Lou Gehrig's disease.
Apoptosis may also play a role in amyotrophic lateral sclerosis (ALS), the neurodegenerative disorder better known as Lou Gehrig's disease. In 1993, researchers found that an inherited form of ALS results from mutations in an enzyme called superoxide dismutase (SN: 3/6/93, p.
French, MD, who predeceased her in 2005 and who also valiantly fought ALS for nine years; two brothers, Richard South of Pittsburgh, Pa., and Furman South III, of Sewickley, Pa.; a sister, Helen Straub of Allison Park, Pa.; four grandchildren, Taylor, Lauren, Cameron and Lily; as well as many nieces and nephews and a dedicated group of loving caregivers who made it possible for her to remain in her own home, living with her family despite Lou Gehrig's disease.
The ALS Association (ALSA) has unveiled a dynamic new logo and theme that underscore its leadership, vision, and commitment in the fight against Lou Gehrig's disease. This is the first time the association has rebranded its identity since its founding in 1985.
After decades of disappointment, researchers are proclaiming a "first step" toward a remedy for Lou Gehrig's disease. In a recent study of nearly 1,000 people, a promising drug has briefly prolonged the lives of sufferers.
The Muscular Dystrophy Association will honor local individuals and a company for outstanding contributions in the effort eradicate ALS (amyotrophic lateral sclerosis, or Lou Gehrig's disease).
Amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative condition also known as Lou Gehrig's disease, may use just such a strategy as it slowly kills the body's motor neurons -- specialized nerve cells that control the muscles.
Jacques, 67, of 24 Farnsworth Road, Templeton, died Saturday, June 23rd, in his residence following a courageous battle with Lou Gehrig's Disease (ALS).