Both
Losartan Potassium and
Losartan Potassium/Hydrochlorothiazide combination tablets are used to treat hypertension and hypertensive patients with left ventricular hypertrophy.
Both candesartan and
losartan significantly reversed these change with non-significant difference in-between (Table I).
- India-based Vivimed Life Sciences Pvt Ltd is recalling 19 lots of
Losartan Potassium Tablets USP 25 mg, 50 mg, and 100 mg to consumer level due to the detection of N-Nitroso-N-methyl-4-aminobutyric acid, a possible process impurity or contaminant in an active pharmaceutical ingredient manufactured by Hetero Labs Ltd (API manufacturer), that is above the US Food and Drug Administration's interim acceptable exposure limit of 9.82 ppm, the company said.
However, for
Losartan, FDA is currently accepting an interim specification of NMBA at 9.82 ppm versus 0.96 ppm, which would be the limit based on the TDI (total daily intake) of 96 ng/day.
Teva Pharmaceuticals USA, a subsidiary of Teva Pharmaceutical Industries, has started a voluntary recall of 35 lots of bulk
Losartan Potassium USP Tablets (6 lots of 25mg strength and 29 lots of 100mg strength) in the United States, it was reported on Friday.
Losartan has a modest uricosuric effect and can modestly lower uric acid levels.
'There's only one
losartan product in Malaysia and that's Lostad HCT 50/12.5 mg film-coated tablets.
At the time of the announcement, FDA said Camber Pharmaceuticals had not received adverse event reports associated with the recall, but the agency did note the following: "This tablet mix-up may pose a safety risk as taking
losartan tablets when not prescribed has the potential to cause renal dysfunction, elevated potassium levels and low blood pressure.
There is a safety risk because taking
losartan when not prescribed can cause renal dysfunction, elevated potassium levels, and low blood pressure.
"Valsartan falls under a class of medication called angiotensin II receptor blocker (ARBs) and the other drugs in this class are
losartan, candesartan, azilsartan, eprosartan, irbesartan, telmisartan and olmesartan.
Diclofenac decreases the antihypertensive effect of
losartan by opposing drug effects.
It is known that renin-angiotensin system (RAS) blockers, particularly angiotensin II (Ang II) antagonists such as
losartan, can slow down the progression of ESRD [2].
