losartan


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losartan

 [lo-sahr´tan]
an angiotensin II receptor antagonist used as an antihypertensive; used as the potassium salt.

losartan

(lō-sär′tăn)
n.
An angiotensin II receptor blocker drug, C22H23ClN6O, used in the form of its potassium salt to treat hypertension.

losartan

Cozaar® Pharmacology A sartan which blocks angiotensin II–A-II from binding to AT1, ↓ proteinuria and filtration fraction, inhibits secretion of aldosterone by the adrenal cortex, and ↑ uric acid excretion; in Pts with CHF, losartan ↓ afterload, ↑ cardiac output–effects shared by ACE inhibitors—and prevent left ventricular hypertrophy Side effects Vertigo. See Angiotensin II receptor antagonist, ELITE.

losartan

An angiotensin II antagonist drug used to treat high blood pressure (HYPERTENSION). In the LIFE trial of this drug, reported on in 2003, a subgroup of diabetic patients taking the drug showed a 37 percent reduction in mortality from heart attacks or strokes and a 39 percent reduction in overall mortality over people on other treatment. The drug appears to be effective in preventing sudden death from heart arrhythmias. A brand name is Cozaar. The drug is available combined with the diuretic drug HYDROCHLOROTHIAZIDE under the brand name Cozaar-Comp.
References in periodicals archive ?
Both Losartan Potassium and Losartan Potassium/Hydrochlorothiazide combination tablets are used to treat hypertension and hypertensive patients with left ventricular hypertrophy.
- India-based Vivimed Life Sciences Pvt Ltd is recalling 19 lots of Losartan Potassium Tablets USP 25 mg, 50 mg, and 100 mg to consumer level due to the detection of N-Nitroso-N-methyl-4-aminobutyric acid, a possible process impurity or contaminant in an active pharmaceutical ingredient manufactured by Hetero Labs Ltd (API manufacturer), that is above the US Food and Drug Administration's interim acceptable exposure limit of 9.82 ppm, the company said.
However, for Losartan, FDA is currently accepting an interim specification of NMBA at 9.82 ppm versus 0.96 ppm, which would be the limit based on the TDI (total daily intake) of 96 ng/day.
Teva Pharmaceuticals USA, a subsidiary of Teva Pharmaceutical Industries, has started a voluntary recall of 35 lots of bulk Losartan Potassium USP Tablets (6 lots of 25mg strength and 29 lots of 100mg strength) in the United States, it was reported on Friday.
Losartan has a modest uricosuric effect and can modestly lower uric acid levels.
'There's only one losartan product in Malaysia and that's Lostad HCT 50/12.5 mg film-coated tablets.
At the time of the announcement, FDA said Camber Pharmaceuticals had not received adverse event reports associated with the recall, but the agency did note the following: "This tablet mix-up may pose a safety risk as taking losartan tablets when not prescribed has the potential to cause renal dysfunction, elevated potassium levels and low blood pressure.
There is a safety risk because taking losartan when not prescribed can cause renal dysfunction, elevated potassium levels, and low blood pressure.
"Valsartan falls under a class of medication called angiotensin II receptor blocker (ARBs) and the other drugs in this class are losartan, candesartan, azilsartan, eprosartan, irbesartan, telmisartan and olmesartan.
Diclofenac decreases the antihypertensive effect of losartan by opposing drug effects.
It is known that renin-angiotensin system (RAS) blockers, particularly angiotensin II (Ang II) antagonists such as losartan, can slow down the progression of ESRD [2].