Major Th2 cytokines, IL-4 and IL-13, downregulate the expression of FLG, the CE components (loricrin and involucrin), cell adhesion molecules (ZO-1), and ceramide lipids.
Thus, ZNF750 knockdown downregulates the expression of epidermal barrier-related proteins including FLG, loricrin, and SPINK5 .
Expressions of loricrin
and involucrin in patients with atopic dermatitis-like graft-versus-host disease and lichen planus-like graft-versus-host disease
and involucrin are proteins important for skin barrier formation and integrity.
The most abundant cell envelope proteins are loricrin
, involucrin and small proline rich proteins.
By additional proteolysis and sequencing, we have found many cross-links within involucrin and between such proteins as involucrin and desmoplakin, or cystatin [Alpha], or envoplakin, or loricrin
Anionic surfactants like sodium lauryl sulphate (SLS) can damage protein structures such as keratin, involucrin, prohlaggrin, and loricrin
, exposing new water binding sites and causing hyperhydration of the stratum corneum and disorganization of the lipid bilayers [13-16].
Key words Short height, loricrin
, progressive symmetrical erythrokeratoderma
A positive family history may be elicited in only about 50 percent patients, rest of cases are due to spontaneous mutation of the loricrin
is a major structural component of the cornified cell envelope, formed beneath the plasma membrane of stratified squamous epithelial cells during terminal differentiation.