loricrin


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loricrin

Dermatology An insoluble glycine/serine-rich transglutaminase substrate protein cross-linked to the cornified cell envelope of the upper dermis
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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Major Th2 cytokines, IL-4 and IL-13, downregulate the expression of FLG, the CE components (loricrin and involucrin), cell adhesion molecules (ZO-1), and ceramide lipids.
Thus, ZNF750 knockdown downregulates the expression of epidermal barrier-related proteins including FLG, loricrin, and SPINK5 [118].
Expressions of loricrin and involucrin in patients with atopic dermatitis-like graft-versus-host disease and lichen planus-like graft-versus-host disease
The most abundant cell envelope proteins are loricrin, involucrin and small proline rich proteins.
By additional proteolysis and sequencing, we have found many cross-links within involucrin and between such proteins as involucrin and desmoplakin, or cystatin [Alpha], or envoplakin, or loricrin and SPRs.
Anionic surfactants like sodium lauryl sulphate (SLS) can damage protein structures such as keratin, involucrin, prohlaggrin, and loricrin, exposing new water binding sites and causing hyperhydration of the stratum corneum and disorganization of the lipid bilayers [13-16].
Key words Short height, loricrin, progressive symmetrical erythrokeratoderma
A positive family history may be elicited in only about 50 percent patients, rest of cases are due to spontaneous mutation of the loricrin gene.
Loricrin is a major structural component of the cornified cell envelope, formed beneath the plasma membrane of stratified squamous epithelial cells during terminal differentiation.