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Related to Lomotil: Diphenoxylate


trademark for combination preparations of diphenoxylate hydrochloride and atropine sulfate, used in treatment of diarrhea.

diphenoxylate hydrochloride and atropine sulfate (co-phenotrope (UK))

Lomotil, Lonox

Pharmacologic class: Anticholinergic, meperidine congener

Therapeutic class: Antidiarrheal

Controlled substance schedule V

Pregnancy risk category C


Acts on smooth muscle of GI tract by decreasing peristalsis, which inhibits motility. (Small amount of atropine is added to reduce abuse potential.)


Liquid: 2.5 mg diphenoxylate and 0.025 mg atropine/5 ml

Tablets: 2.5 mg diphenoxylate and 0.025 mg atropine

Indications and dosages


Adults: Initially, 5 mg P.O. three to four times daily, then 5 mg/day as needed (not to exceed 20 mg/day). Decrease dosage when desired response occurs.

Children: Initially, 0.3 to 0.4 mg/kg P.O. (liquid only) daily in four divided doses. Decrease dosage when desired response occurs.

Dosage adjustment

• Elderly patients


• Hypersensitivity to drug

• Obstructive jaundice

• Diarrhea associated with pseudomembranous colitis or enterotoxinproducing bacteria

• Angle-closure glaucoma

• Concurrent MAO inhibitor use

• Children younger than age 2


Use cautiously in:

• inflammatory bowel disease; prostatic hypertrophy; severe hepatic disease (use with extreme caution)

• concurrent use of drugs that cause physical dependence; history of physical drug dependence

• elderly patients

• pregnant or breastfeeding patients

• children (safety not established in children younger than age 12).


Don't confuse brand name Lomotil with Lamictal (an anticonvulsant). Serious errors have been reported.

• Withhold drug if patient has severe fluid or electrolyte imbalance.

• Administer with food if GI upset occurs.

Don't give within 14 days of MAO inhibitors.

Adverse reactions

CNS: dizziness, confusion, drowsiness, headache, insomnia, nervousness

CV: tachycardia

EENT: blurred vision, dry eyes

GI: nausea, vomiting, constipation, epigastric distress, ileus, dry mouth

GU: urinary retention

Skin: flushing


Drug-drug. CNS depressants (including antihistamines, sedative-hypnotics, opioids): increased CNS depression

Anticholinergic-like drugs (including tricyclic antidepressants, disopyramide): increased anticholinergic effects

MAO inhibitors: hypertensive crisis

Drug-diagnostic tests. Amylase: increased level

Drug-herbs. Angel's trumpet, jimsonweed, scopolia: increased anticholinergic effects

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

Assess for and report abdominal distention and signs or symptoms of decreased peristalsis.

• Watch for signs and symptoms of dehydration.

• Assess frequency and consistency of bowel movements.

Patient teaching

• Instruct patient to report persistent diarrhea.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Tell patient that prolonged use may lead to dependence.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.


A trademark for a drug combination of diphenoxylate hydrochloride and a sulfate salt of atropine.


A brand name for a mixture of DIPHENOXYLATE and ATROPINE.
References in periodicals archive ?
Twenty-six patients received empirical treatment in the form of probiotics, fiber supplement, Lomotil, and loperamide.
Never travel without Lomotil, the anti-diarrhea medicine that comes in tiny pills.
During the first half of 2000 the company received an ANDA for diphenoxylate with atropine tablets, the generic equivalent to Lomotil, a product used for diarrhea/colon spasms.
Medications to slow down the GI tract (such as Lomotil and Imodium) may also be helpful.
These drugs include propranolol (one or two 160-mg tablets), verapamil (one or two 240-mg tablets), chloroquine (500-mg tablet), clonidine (0.3-mg tablet), Lomotil (2.5-mg tablet), glyburide (5 mg), and theophylline (500-mg tablet).
If bulk-formers don't relieve diarrhea, your doctor may suggest short-term use of medications that slow the bowel muscles, such as Kaopectate or Lomotil.
Continuing reports about dispensing errors over confusion with lamotrigine (Lamictal) and the antifungal terbinafine (Lamisil) have prompted the Food and Drug Administration to issue a warning in early December, Pharmacists may give lamotrigine in error to patients with prescriptions for a number of other drugs, most commonly Lamisil, lamivudine, Ludiomil, labetalol, and Lomotil, the FDA cautioned in its Safety Alert (www.fda.gov/medwatch/SAFETY/2001/safety01.htm#lamict).
Antimotility agents such as loperamide (Imodium) and diphenoxylate with atropine (Lomotil) act to slow intraluminal flow of intestinal contents by increasing segmenting contractions in the intestine.
Lomotil, which is taken to relieve diarrhea, contains diphenoxylate.
Lomotil is one brand, but use these only after you have seen your GP.
"But if it wouldn't be a problem, it would be easier for me to get my Darvocet for pain now, and my Lomotil."