I treated her for of Lofgren's syndrome
. Oral administration of prednisolone was initiated.
Acute sarcoidosis: Lofgren's syndrome
. Br J Hosp Med 2015; 76: 154-8.
There are several presentations of sarcoidosis, most notably an acute variant known as Lofgren's Syndrome
, which is characterized by arthritis, erythema nodosum, and hilar adenopathy.
This patient has Lofgren's syndrome (acute presentation of sarcoidosis).
In another study, the same investigators reported on the clinical features and course of Lofgren's syndrome in 186 patients.
Classic sarcoid associated anterior uveitis may present either as acute iridocyclitis, which is mostly seen in Lofgren's syndrome
, or as a chronic granulomatous uveitis with mutton-fat keratic precipitates .
Histological demonstration of granuloma was not required for patients with classic features of Lofgren's syndrome, defined as bilateral hilar lymphadenopathy with fever, erythema nodosum, and/or ankle arthritis.
Investigation of intracellular expression of IL-17A and IFN-[gamma] after mitogen stimulation was performed in a subgroup of the patients: sarcoidosis: N = 23 (3 patients with Lofgren's syndrome); other DPLDs: N = 11 (hypersensitivity pneumonitis: N = 3; idiopathic pulmonary fibrosis: N = 1; connective tissue disease or medication associated lung disease: N = 2; unspecified DPLD: N = 5).
It is important to identify Lofgren's syndrome
(consisting of erythema nodosum, bilateral hilar adenopathy, migratory polyarthritis and fever), as not only does it have a good prognosis, but it is also made without the need for histological proof.
(2) In most cases, arthritis occurs as a part of Lofgren's syndrome
, which is characterized by bilateral hilar lymphadenopathy and erythema nodosum.
The combination of erythema nodosum, periarticular ankle inflammation, and mediastinal lymphadenopathy is designated as Lofgren's syndrome
, which usually has a self-limiting course with spontaneous resolution.