Nitya Viswanathan, pediatric resident at Baylor, will present: Description of Aortic Root Growth and Outcomes in a Cohort of Pediatric Patients with Loeys-Dietz
Syndrome and Rates and Risk Factors for Faster Aortic Root Growth in Pediatric Patients with Marfan Syndrome.
It was found that mutations in the genes that lead to abnormal TGF-beta signaling are also keys to Marfan and Loeys-Dietz
syndromes, genetic conditions marked by blood vessel laxity and dangerous stretching of the aorta, the body's largest blood vessel.
We hypothesise that the 18th dynasty royal family of the new Egyptian kingdom might have suffered from Loeys-Dietz syndrome, which might solve the medical mystery of the 18th dynasty.
Loeys-Dietz syndrome (LDS) is an autosomal dominant inherited disorder of connective tissue that has been recently introduced as an important cause of familial aortic aneurysm.
Can Loeys-Dietz syndrome justify the pathologies in Akhenaten and his family?
Based on the foregoing findings, the possibility of Loeys-Dietz syndrome or an abnormality in the SMAD3 gene should be considered as the underlying disease of this Egyptian royal family.
The Loeys-Dietz syndrome: an update for the clinician.
The known risk factors include the following genetically-based conditions: bicuspid aortic valve families, familial thoracic aortic aneurysm and dissection (TAAD), Ehlers-Danlos syndrome, Loeys-Dietz
syndrome, Marfan syndrome, and Turners syndrome.
Another arm of their studies involves the creation of disease-specific stem cell lines for Marfan Syndrome and Loeys-Dietz
Syndrome, which affect both bone and cardiovascular development in those with the diseases.
Dietz also was the first to observe and describe a related genetic disorder that bears their names, Loeys-Dietz
As a result, Gold's Gym will be making a donation on behalf of Steve Novak to the Loeys-Dietz Syndrome Foundation.
More importantly, I'm glad for the opportunity to give back to the Loeys-Dietz Syndrome Foundation, a cause that's really close to me.