(b) Genome-wide LOD score
plot of single-QTL scans for plasma CHO concentrations (solid lines: cross direction as an additive covariate; broken lines: cross direction and body weight as additive covariates).
In the 1st pass, the LOD score
of this QTL was 1.06.
Logarithm of odds (LOD) scores (/-axis) indicate a high association with microsatellite D19Mit53 on chromosome 19; LOD score
= 5.78, ***p = 0.0002.
The unstratified analysis of the RET families at the 42 cM locus yields a LOD score
of 3.6 and an HLOD of 5.0, indicating substantial locus heterogeneity in the data.
A maximum two-point LOD score
of 1.8 at a recombination fraction of =0 was obtained for the marker D2S2238 for this family.
The two-point LOD score
4.04 was achieved with two markers D3S2314 and D3S3592.
Hansen y Eriksen (58), encontraron ligamiento de HLA y GLO1 (del ingles Glyoxalase I) con un LOD score
de 14.6, lo que pudiera sugerir que genes en la region del HLA o muy cercanos a ella pudieran estar involucrados en la etiologia del autismo como fue sugerido posteriormente por el estudio de Junaid y col.
CERVUS calculates a statistic delta ([DELTA]), which discriminates between non-excluded males by subtracting the LOD score
of the second most-likely male from the LOD score
of the most-likely male.
The allele data obtained from the IRMF panel was first entered in an excel file and then analyzed with CRI-MAP version 2.4.using an initial threshold LOD score
of 3.0 to identify linkage groups (LG) and determine marker order.
Presence of renal failure (as measured by serum creatinine), serum albumin, LOD score
, APACHE II score and use of heparin, frusemide and beta-lactam antibiotics were not independent risk factors for development of thrombocytopenia after adjusting for age and gender.
QTL were deemed to exist only at positions where a LOD score
exceeded the corresponding significance threshold.
The LOD score
was only 2 in a broader anxiety disorder sample of 62 Icelandic families with diagnoses including panic disorder, agoraphobia, simple phobia, social phobia, generalized anxiety disorder, and somatoform pain, which was highly comorbid with anxiety in the sample (Am.