The side effects appearing after administering lidocaine are the cause of, very often premature, classification of the patient as "allergic" to
local anaesthetics, even though there is no evidence in detailed diagnostic examination.
The effect of nerve sheath on the action of
local anaesthetics. J Pharmacol Exp Ther 1965;150(1):160-4.
However, in their Cochrane database review, Gurusamy et al13 included 12 randomized controlled trials on use of intraperitoneal
local anaesthetics in patients undergoing elective laparoscopic cholecystectomy.
Accidental lip injury with the use of long acting
local anaesthetic has been reported as one of the adverse events [3].
Combinations of
local anaesthetics have been used to enhance the onset of sensory and motor block.4 Certain drugs may be used as adjuvants to
local anaesthetics to lower the dose of each agent, to enhance the quality and duration of block, to increase the analgesic effect and reducing the need for supplementary analgesics thus decreasing the incidence of adverse reactions.
Positioning the patient, anatomy, and factors affecting spread of
local anaestheticSmith T 2004 Systemic toxic effects of
local anaesthetics Anaesthesia and Intensive Care Medicine 5 (4) 132-136
The exclusion criteria were coagulation disorder, neuromuscular, hepatic and renal disease, hypersensitivity to
local anaesthetic, infection at the injection site, body mass index (BMI) >30 or <18.5 and use of a drug known to interact with neuromuscular blocking drugs.
Local anaesthetics are used to locally desensitise the tissues to allow surgical interventions.
Local anaesthetics, from lidocaine to the more recent ropivacaine, have been used as pre-emptive analgesics since the 1980s.
A risk-benefit assessment of topical percutaneous
local anaesthetics in children.
Furthermore, in the area of
local anaesthetics (where Astra is the world market leader), Zeneca has undertaken to reverse all arrangements relating to Chirocaine, a new long-acting
local anaesthetic which Zeneca licensed-in last year.