hepatotoxicity

(redirected from Liver toxicity)
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Related to Liver toxicity: toxic hepatitis, Toxic liver disease

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē),
The capacity of a drug, chemical, or other exposure to produce injury to the liver. Agents with recognized hepatotoxicity include carbon tetrachloride, alcohol, dantrolene sodium, valproic acid, and isonicotinic acid hydrazide.

hepatotoxicity

(hĕp′ə-tō-tŏk-sĭs′ĭ-tē, hĭ-păt′ō-)
n.
1. The quality or condition of being toxic or destructive to the liver.
2. The capacity of a substance to have damaging effects on the liver.

hep′a·to·tox′ic (-tŏk′sĭk) adj.

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)
The capacity of a drug, chemical, or other exposure to produce injury to the liver.

hepatotoxicity

The state of being poisonous (toxic) to the liver, or the degree to which a substance is toxic to the liver.

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)
Capacity of a drug, chemical, or other exposure to injure the liver.
References in periodicals archive ?
Liver toxicity is considered to be an adverse reaction to a number of substances.
Treatment response and liver toxicity events were compared between different subgroups using Fisher's exact test.
Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells.
Regarding non-cancer health hazards, EPA will evaluate acute toxicity, liver toxicity, thyroid toxicity, reproductive/developmental toxicity, neurotoxicity, immunotoxicity, sensitization, and irritation.
Abacavir (ABC)-induced liver toxicity is a rare event almost exclusively occurring in HLA B*5701-positive patients, (2) with a handful of cases reported in non carriers of the HLA allele risk.
In addition, the defendants are accused of knowing that their products were linked to liver toxicity. In 2013, OxyElitePro had been implicated in liver injuries.
This project will use 3D liver models developed at IBN and computational tools at the NCCT to identify novel predictive biomarkers of human liver toxicity to overcome limitations in existing 2D model tests, which limit their sensitivity, especially over extended periods.
Potentiation of isoniazid- induced liver toxicity by rifampicin in a combinational therapy of antitubercular drugs inwistar rats.
The company also said Zohydro ER does not contain acetaminophen, unlike many immediate-release hydrocodone products, reducing the risk for potential liver toxicity due to overexposure of acetaminophen, added the company.
The study also found that liver cells derived from AAT deficient iPSCs are more sensitive to drugs that cause liver toxicity than liver cells derived from normal iPSCs.
"Triclosan's increasing detection in environmental samples and its increasingly broad use in consumer products may overcome its moderate benefit and present a very real risk of liver toxicity for people, as it does in mice, particularly when combined with other compounds with similar action," said study leader Dr.