hepatotoxicity

(redirected from Liver toxicity)
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Related to Liver toxicity: toxic hepatitis, Toxic liver disease

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē),

The capacity of a drug, chemical, or other exposure to produce injury to the liver. Agents with recognized hepatotoxicity include carbon tetrachloride, alcohol, dantrolene sodium, valproic acid, and isonicotinic acid hydrazide.

Farlex Partner Medical Dictionary © Farlex 2012

hepatotoxicity

(hĕp′ə-tō-tŏk-sĭs′ĭ-tē, hĭ-păt′ō-)

1. The quality or condition of being toxic or destructive to the liver.

2. The capacity of a substance to have damaging effects on the liver.

hep′a·to·tox′ic (-tŏk′sĭk) adj.

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)

The capacity of a drug, chemical, or other exposure to produce injury to the liver.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

hepatotoxicity

The state of being poisonous (toxic) to the liver, or the degree to which a substance is toxic to the liver.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)

Capacity of a drug, chemical, or other exposure to injure the liver.

Medical Dictionary for the Dental Professions © Farlex 2012

References in periodicals archive ?

Liver toxicity is considered to be an adverse reaction to a number of substances.

CBD Could Cause Liver Damage Just Like Other Drugs, Study Reveals

Treatment response and liver toxicity events were compared between different subgroups using Fisher's exact test.

Application of stereotactic ablative radiotherapy in hepatocellular carcinoma patients with child-turcotte-pugh class B liver function

Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells.

EUTOXRISK

Regarding non-cancer health hazards, EPA will evaluate acute toxicity, liver toxicity, thyroid toxicity, reproductive/developmental toxicity, neurotoxicity, immunotoxicity, sensitization, and irritation.

EPA Considers First 10 Chemicals Being Evaluated Under TSCA

After initiating ART, the reported incidence of severe liver toxicity ranges from 2 to 18% [11-13].

Prevalence and Clinical Spectrum of Liver Disease in Nepalese HIV-Sero-Positive Patients Undergoing Antiretroviral Therapy: A Cross-Sectional Hospital Based Study

Abacavir (ABC)-induced liver toxicity is a rare event almost exclusively occurring in HLA B*5701-positive patients, (2) with a handful of cases reported in non carriers of the HLA allele risk.

Abacavir-induced liver toxicity

In addition, the defendants are accused of knowing that their products were linked to liver toxicity. In 2013, OxyElitePro had been implicated in liver injuries.

FDA again protects consumers from dangerous dietary supplements

This project will use 3D liver models developed at IBN and computational tools at the NCCT to identify novel predictive biomarkers of human liver toxicity to overcome limitations in existing 2D model tests, which limit their sensitivity, especially over extended periods.

International Collaboration to Advance Research on Non-Animal Approaches to Chemical Safety Testing

Potentiation of isoniazid- induced liver toxicity by rifampicin in a combinational therapy of antitubercular drugs inwistar rats.

The hepatoprotective role of Silymarin in isoniazid induced liver damage of rabbits

The company also said Zohydro ER does not contain acetaminophen, unlike many immediate-release hydrocodone products, reducing the risk for potential liver toxicity due to overexposure of acetaminophen, added the company.

Pernix Therapeutics Holdings unveils new formulation of Zohydro ER Extended-Release Capsules with BeadTek for the management of pain in the US

The study also found that liver cells derived from AAT deficient iPSCs are more sensitive to drugs that cause liver toxicity than liver cells derived from normal iPSCs.

iPSC model sheds light on genetic lung/liver disease

"Triclosan's increasing detection in environmental samples and its increasingly broad use in consumer products may overcome its moderate benefit and present a very real risk of liver toxicity for people, as it does in mice, particularly when combined with other compounds with similar action," said study leader Dr.