hepatotoxicity

(redirected from Liver toxicity)
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Related to Liver toxicity: toxic hepatitis, Toxic liver disease

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē),

The capacity of a drug, chemical, or other exposure to produce injury to the liver. Agents with recognized hepatotoxicity include carbon tetrachloride, alcohol, dantrolene sodium, valproic acid, and isonicotinic acid hydrazide.

hepatotoxicity

(hĕp′ə-tō-tŏk-sĭs′ĭ-tē, hĭ-păt′ō-)

1. The quality or condition of being toxic or destructive to the liver.

2. The capacity of a substance to have damaging effects on the liver.

hep′a·to·tox′ic (-tŏk′sĭk) adj.

hepatotoxicity

[hep′ətōtoksis′itē]

Etymology: Gk, hēpar + toxikon, poison

the tendency of an agent, usually a drug or alcohol, to have a destructive effect on the liver.

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)

The capacity of a drug, chemical, or other exposure to produce injury to the liver.

hepatotoxicity

The state of being poisonous (toxic) to the liver, or the degree to which a substance is toxic to the liver.

hepatotoxicity (hepˑ··tō·tkˈ·si·sit·ē),

n liver toxicity.

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)

Capacity of a drug, chemical, or other exposure to injure the liver.

References in periodicals archive ?

While HSAs review indicated that there are no major safety concerns when THP-containing herbs are used appropriately, there is some evidence of an association between high levels of THP and liver toxicity in the scientific literature.

Singapore : Hsa Allows Import and Sale of Corydalis Yanhusuo Herb in Singapore From 1 June 2018

Regarding non-cancer health hazards, EPA will evaluate acute toxicity, liver toxicity, thyroid toxicity, reproductive/developmental toxicity, neurotoxicity, immunotoxicity, sensitization, and irritation.

EPA Considers First 10 Chemicals Being Evaluated Under TSCA

The patient did not take concomitant medications after switching to ABC and was not given acetaminophen, a drug known to induce liver toxicity eventually exacerbated by ABC.

Abacavir-induced liver toxicity

Prof Hanry Yu's team at IBN has also developed a novel, rubust system for high-throughput 3D cell culture that facilitates acute liver toxicity testing.

International Collaboration to Advance Research on Non-Animal Approaches to Chemical Safety Testing

Potentiation of isoniazid- induced liver toxicity by rifampicin in a combinational therapy of antitubercular drugs inwistar rats.

The hepatoprotective role of Silymarin in isoniazid induced liver damage of rabbits

Side effects may include drowsiness, vomiting, nausea, liver toxicity and dry eye.

The most common anti-seizure drugs

Doctors at the Keck School of Medicine of USC have identified a protein 'Sab' on the mitochondria of liver cells in mice that, when silenced, protects against liver toxicity usually associated with excess doses of acetaminophen.

New target to prevent drug-induced liver damage identified

ATD's test will be able to provide conclusive diagnosis for up to seven days after an acetaminophen overdose, so a greater number of patients who develop acetaminophen liver toxicity can be appropriately treated.

Little Rock startup gets $1.69M NIH grant

Serum POPs levels were also positively correlated with liver toxicity markers and lipid parameters, independently of age and body mass index.

POPs in obese individuals during weight loss

No signals of liver toxicity were reportedly detected to date in the 1 mg group.

Repros Therapeutics Inc plans to begin dosing of second cohort in low 3mg dose study of Proellex

It is a proprietary formulation of the prodrug T undecanoate (TU), and if approved Clarus intends to market it as a safer alternative to existing testosterone replacement products, some of which are associated with liver toxicity, inconsistent absorption, inconvenient dosing, and potentially unsafe transference of testosterone to children.

IPO sector

The Criigen paper is a follow up to a previous study highlighting signs of kidney and liver toxicity following the consumption of GM food.