STK11

(redirected from Liver kinase B1)

STK11

A gene on chromosome 19p13.3 that encodes a ubiquitously expressed serine/threonine-protein kinase which controls the activity of AMP-activated protein kinase (AMPK) family members, playing a role in various cellular processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. STK11 acts by phosphorylating the T-loop of AMPK family proteins, upregulating their activity.

Molecular pathology
Defects in STK11 are a cause of Peutz-Jeghers syndrome; it has been linked to testicular germ cell tumours and sporadically to non-small cell carcinomas of the lung. Defects in STK11 also promote carcinogenesis, including lung cancer progression and metastasis, and confers in lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The team focused on the tumor suppressor liver kinase B1 (LKB1), a protein that controls cell growth and metabolism.
This enzyme may be activated by [Ca.sup.++]/calmodulin-dependent protein kinase (CaMK), liver kinase B1, protein kinase C (PKC), heat shock protein 90 (HSP90), and nitric oxide (NO) (3,5,8,16,25).
Chalcones attenuate lipid accumulation by activating the liver kinase B1 (LKB1) / AMP-activated protein kinase (AMPK) signalling pathway, thereby reducing the development of hyperlipidaemia and diabetes (Zhang et al., 2014).
Upstream kinases also play a role in the activation of AMPK with liver kinase B1 (LKB1) and calcium calmodulin-dependent protein kinase [beta] (CAMKK[beta]) both catalyzing the activating phosphorylation of threonine 172, the former due to changes in energy state and the latter due to calcium influxes [158,159].
We also show that metformin mediated effect on AMPK is dependent on LKB1(Liver kinase B1) as it failed to activate AMPK-ACC pathway and cell cycle arrest in LKB1 null mouse embryo fibroblasts (mefs).