Little's disease


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Little's disease

 [lit´'lz]
congenital spastic stiffness of the limbs, a form of cerebral spastic paralysis due to lack of development of the pyramidal tracts.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
A type of cerebral palsy with agenesis of the lower motor neurons in the legs, which affects ± 300,000, US
Aetiology Congenital cerebrovascular malformations and immune-related kernicterus account for some cases
DiffDx Brain tumours, ‘floppy infant’ syndromes, leukodystrophy, muscular dystrophy
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Little's disease

Bilateral congenital spastic diplegia A type of cerebral palsy with agenesis of the lower motor neurons in the legs, which affects ± 300,000, US; congenital cerebrovascular malformations and immune-related kernicterus account for some cases Clinical Spasticity, muscle weakness, mental retardation, and ocular defects, due to neonatal hypoxia, mechanical trauma and prematurity DiffDx Brain tumors, 'floppy infant' syndromes, leukodystrophy, muscular dystrophy. See Cerebral palsy, Floppy infant.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Little's disease

A common form of spastic paralysis (CEREBRAL PALSY) (William John Little, 1810–94, English surgeon).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005