Lisch nodule


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Lisch nod·ule

(lish),
iris hamartomas typically seen in type 1 neurofibromatosis.

Lisch nod·ule

(lish nod'yūl)
Iris hamartomas typically seen in association with type 1 neurofibromatosis.

Lisch nodule

(lish)
[Karl Lisch, Ger. scientist, 1907–1999]
A melanocytic hamartoma projecting from the surface of the iris of the eye. It is a well-defined, dome-shaped elevation that is clear to yellow or brown. These growths, which do not cause ophthalmological complications, may be seen without magnification, but examination with use of a slit lamp is needed to differentiate them from nevi of the iris. Lisch nodules are found only in patients with neurofibromatosis, type 1.

Lisch,

Karl, Austrian ophthalmologist, 1907-1999.
Lisch nodule - iris hamartomas typically seen in type 1 neurofibromatosis. Synonym(s): Sakurai-Lisch nodule
Sakurai-Lisch nodule - Synonym(s): Lisch nodule

Sakurai,

Japanese ophthalmologist.
Sakurai-Lisch nodule - Synonym(s): Lisch nodule
References in periodicals archive ?
The patient was then found to have multiple neurofibromata, and a Lisch nodule as well.
Lisch nodule was present in 30 out of 50 patients (60%) examined by slit lamp, 1 patients screened with cranial CT had ventricular dilatation with aqueductal stenosis and all patient had axillary or inguinal freckling.
Caption: Figure 2: (a) Microsection showing bundles of wavy spindle cells with serpentine nuclei in fascicles (H&E, x10x), (b) Strong S-100 positivity of tumor cells (x40x), (c) cafe au lait macule (arrow) in the back, (d) axillary freckle, (e) Lisch nodule (arrow) in slit lamp examination, and (f) father of patient with multiple cutaneous neurofibromas.
Consultation with ophthalmologist found no Lisch nodule (iris hamartoma).
Ophthalmologic examination revealed Lisch nodule present in both eyes.
Melanocytic hamartomas of the iris (Lisch nodules), axillary freckling (Crowe's sign), or multiple cutaneous neurofibromas serve as additional clues to neurofibromatosis.
Her ophthalmological examination revealed the presence of Lisch nodules on her iris.
Supportive tests include an ophthalmologic exam to detect Lisch nodules and cataracts.
The differential diagnosis of iris mammillations is from Lisch nodules, iris nevi, iris melanoma, Brushfield flecks, retinoblastoma, and the Cogan-Reese (ICE) syndrome [1-7].
Second, patients of neurofibromatosis often have typical skin manifestations of cafe au lait spots or Lisch nodules. Third, the lack of neural foramina erosion or widening on MRI helped us rule out the diagnosis of neurofibromatosis.
Clinically, NF-1 is characterized by cafe-au-lait spots, freckling, skin neurofibroma, plexiform neurofibroma, bony defects, Lisch nodules, and tumors of the central nervous system.