Lisch nodule


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Lisch nod·ule

(lish),
iris hamartomas typically seen in type 1 neurofibromatosis.

Lisch nod·ule

(lish nod'yūl)
Iris hamartomas typically seen in association with type 1 neurofibromatosis.

Lisch nodule

(lish)
[Karl Lisch, Ger. scientist, 1907–1999]
A melanocytic hamartoma projecting from the surface of the iris of the eye. It is a well-defined, dome-shaped elevation that is clear to yellow or brown. These growths, which do not cause ophthalmological complications, may be seen without magnification, but examination with use of a slit lamp is needed to differentiate them from nevi of the iris. Lisch nodules are found only in patients with neurofibromatosis, type 1.

Lisch,

Karl, Austrian ophthalmologist, 1907-1999.
Lisch nodule - iris hamartomas typically seen in type 1 neurofibromatosis. Synonym(s): Sakurai-Lisch nodule
Sakurai-Lisch nodule - Synonym(s): Lisch nodule

Sakurai,

Japanese ophthalmologist.
Sakurai-Lisch nodule - Synonym(s): Lisch nodule
References in periodicals archive ?
Lisch nodule was present in 30 out of 50 patients (60%) examined by slit lamp, 1 patients screened with cranial CT had ventricular dilatation with aqueductal stenosis and all patient had axillary or inguinal freckling.
Caption: Figure 2: (a) Microsection showing bundles of wavy spindle cells with serpentine nuclei in fascicles (H&E, x10x), (b) Strong S-100 positivity of tumor cells (x40x), (c) cafe au lait macule (arrow) in the back, (d) axillary freckle, (e) Lisch nodule (arrow) in slit lamp examination, and (f) father of patient with multiple cutaneous neurofibromas.
Consultation with ophthalmologist found no Lisch nodule (iris hamartoma).
Physical examination revealed multiple neurofibromas (including plexiform variety) of the chest and trunk, multiple cafe-au-lait spots of the axillary and gluteal areas and trunk, scoliosis and a Lisch nodule of the right eye.
Supportive tests include an ophthalmologic exam to detect Lisch nodules and cataracts.
3) NF1 is characterized by multiple cafe-au-lait macules, axillary freckling, neurofibromas, and Lisch nodules (pigmented iris hamartomas).
Second, patients of neurofibromatosis often have typical skin manifestations of cafe au lait spots or Lisch nodules.
Clinically, NF-1 is characterized by cafe-au-lait spots, freckling, skin neurofibroma, plexiform neurofibroma, bony defects, Lisch nodules, and tumors of the central nervous system.
No Lisch nodules or astrocytic hamartomas were noted during the ophthalmology exam.
Ophthalmologic examination revealed no Lisch nodules.
Lisch nodules are innocuous iris hamartomas evident in patients older than 2 years (Fig.
The disease can manifest as one of several types of lesions, including cafe au lair spots, cutaneous tumors, plexiform lesions, axillary freckling, Lisch nodules of the iris, optic gliomas, and bony abnormalities.