LiquiVent

LiquiVent®

Perflubron, see there.
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Alliance is investigating the use of LiquiVent, a perfluorochemical liquid that spreads easily through the airways, as a safe vehicle for delivery of genes and other drugs directly into the lungs.
The method used in this study involved administering a gene transfer vector into the lungs, followed by a single instillation of LiquiVent," Dr.
We administered a single dose of LiquiVent to spontaneously breathing subjects and found that the product was well tolerated and without obvious adverse clinical effect," Weiss reported.
Efficacy data from the study revealed that PLV with LiquiVent did not meet either the primary study endpoint for improvement in 'ventilator free days' or the secondary endpoint of improvement in 28-day mortality.
While we are disappointed with the results of the study and we do not contemplate further PLV studies with adult ARDS patients, Alliance intends to pursue the use of LiquiVent for other indications in the treatment of lung disease,' said Duane J.
Efficacy data from the study revealed that PLV with LiquiVent did not meet either the primary study endpoint for improvement in "ventilator free days" or the secondary endpoint of improvement in 28-day mortality.
Mortality in adult ARDS patients was widely accepted at 40 percent or more when this clinical trial was initiated," said Mark Wedel, MD, JD, FACP, the LiquiVent program director.
LiquiVent is an intrapulmonary "liquid ventilation" agent for treatment of acute lung injury and acute respiratory distress syndrome.
In regard to LiquiVent, we are compiling and analyzing the data from our recently completed Phase 2-3 clinical study, and we anticipate that preliminary results will be available this spring.
OPTISON(R), the only approved perfluorochemical-based ultrasound contrast agent, is a welcome addition to our family of PFC products in late-stage clinical development, which includes Imavist, Oxygent, and LiquiVent.
LiquiVent is an oxygen-carrying liquid drug (perflubron) being developed under U.
LiquiVent is administered via Alliance's proprietary Partial Liquid Ventilation(TM) technique directly into the lungs of a patient who is being supported by a mechanical ventilator.