lipoxygenase

(redirected from Lipoxygenases)

lipoxygenase

 [lĭ-poks´ĭ-jĕ-nās]
an enzyme that catalyzes the oxidation of polyunsaturated fatty acids to form a peroxide of the acid.

lipooxygenase

, lipoxygenase (lip-ooks'ĭ-jen-ās, lip-oks'ĭ-jen-ās),
Any of a family of enzymes that convert unsaturated fatty acids to peroxides; important in the synthesis of leukotrienes from arachidonic acid.
[lipo- + oxygen + -ase]

li·pox·y·ge·nase

(li-poks'ē-jĕ-nās)
An enzyme that catalyzes the oxidation of unsaturated fatty acids with O2 to yield hydroperoxides of the fatty acids.
Synonym(s): lipoxidase.

lipoxygenase

An enzyme that catalyzes the production of leukotrienes from arachidonic acid.

li·pox·y·ge·nase

(li-poks'ē-jĕ-nās)
An enzyme that catalyzes the oxidation of unsaturated fatty acids with O2 to yield hydroperoxides of the fatty acids.
Synonym(s): lipoxidase.
References in periodicals archive ?
Plant lipases and lipoxygenases are the main enzymes responsible for change of FA because plant lipases release FA from damaged tissues after cutting and followed ensiling (CHOW et al., 2004) and plant lipoxygenases oxidize FA (FEUSSNER & WASTERNACK, 2002).
It happens through the changes in substrates availability and the effect on the activity of basic enzymes: cyclooxygenases and lipoxygenases [5].
Several enzymes are involved in this regulation of inflammation, cyclooxygenases 1 and 2 [1], lipoxygenases [1], cytochrome P 450 (CYP) epoxygenases and [alpha]-hydroxylases [2], and also the nonenzymatic processes of AA metabolism like the free radicalcatalyzed peroxidation [3].
Conrad, "The arachidonate 12/15 lipoxygenases. A review of tissue expression and biologic function," Clinical Reviews in Allergy & Immunology, vol.
JAs originate from a-linolenic acid released from the lipid pool of plant cells by lipases and are subsequently oxygenated by lipoxygenases (LOXs) to form hydroperoxide derivatives (cyclopentanones) [3-5].
Nadler, "Lipoxygenases and lipid signaling in vascular cells in diabetes," Frontiers in Bioscience, vol.
Among lipoxygenases, 12/15-LOX seems to play a particular role in the brain and it is also called a "neuronal isoform" [2].
At the cellular level, multiple mechanisms including lipoxygenases are involved in differentiation of preadipocytes into adipocytes and in their intracellular lipid accumulation [33].
Drugs that target lipoxygenases and leukotrienes as emerging therapies for asthma and cancer.