fat soluble

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fat soluble

Able to be dissolved in fats or fat solvents. Four of the vitamins, A, D, E and K, are fat soluble.
References in periodicals archive ?
It was further found that the lipophilicity of the compounds has significant effects on the ionization of the molecules.
Statins as neuroprotectants: A comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death.
According to the results, compounds 1-12 have adequate solubility to meet pharmacokinetic requirements, presenting sufficient hydrophilicity to interact with biological fluids (plasma) and lipophilicity suitable to interact with hydrophobic (cell membrane) surfaces.
This delay in onset of action might be explained by the high lipophilicity that leads to distribution out of blood, or as they are prodrugs that metabolized via N-Dealkylation into the active forms (M1).
[31] also indicated that the high lipophilicity of VAAP facilitated its passive diffusion, resulting in increased accumulation of platinum in the cells.
The lipophilicity of [[sup.18]F][AmBF.sub.3]-TEG-ES may endow it with suitable pharmacokinetics in vivo for tumor imaging.
An excellent fluorescent probe for A[beta] plaques must meet the following requirements [18, 21, 23]: (1) selective targeting of A[beta] plaques, (2) acceptable lipophilicity (log P value between 1 and 3), (3) high-affinity binding, (4) straightforward synthesis, and (5) a significant change in fluorescent properties upon binding to A[beta] deposits.
To obtain features from ligands, we first use four measurements: molecular weight, XlogP (a measure of the molecule's lipophilicity and solubility), hydrogen bond donors, and hydrogen bond acceptors.
This is due to the size of chlorine atom that is bigger than that of fluorine, thus exerting a significant impact on the London dispersion force and also the lipophilicity [17, 18].
Cruickshank, "The clinical importance of cardioselectivity and lipophilicity in beta blockers," American Heart Journal, vol.
A DILI score model was created to better predict the potential of a drug to cause liver injury and the severity of the injury based on the lipophilicity of the drug (logP [greater than or equal to] 3), covalent binding of reactive metabolites, and the daily dose of the oral medication ([greater than or equal to] 100 mg) [5].
Ropivacaine has same efficacy as compared to bupivacaine but due to reduced lipophilicity it is less cardio toxic and neurotoxic20.