LPIN2

(redirected from Lipin-2)

LPIN2

A gene on chromosome 18p11.31 that encodes a magnesium-dependent phosphatidate phosphatase, which converts phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine synthesis in the endoplasmic reticulum, and which acts a nuclear transcriptional coactivator for PPARGC1A/PPARA, modulating lipid metabolism-related gene expression.

Molecular pathology
LPIN2 mutations may cause lipodystrophy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The lipin-2 protein may be involved with oxidative stress response and mitosis (12), but it appears to be independent of the inflammasome.
This case suggests that abnormal lipin-2 protein may be involved in an inflammatory cascade that is abnormal in adult-onset Still's disease.
These authors demonstrated that lipin-2 may be involved in regulation of triglyceride concentrations and activation of the proinflammatory cytokines TNF-[alpha] and IL-6.
Meana et al., "Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages," The Journal of Biological Chemistry, vol.
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. J.
Majeed syndrome is a rare autosomal recessive clinical entity, first identified in 1989, caused by mutations in the LPIN2 gene, localized on the short arm of chromosome 18, which codifies the lipin-2 protein, expressed in liver, kidney, gastrointestinal tract, lymphatic tissue, and bone marrow [126].