LPIN2

(redirected from Lipin-2)

LPIN2

A gene on chromosome 18p11.31 that encodes a magnesium-dependent phosphatidate phosphatase, which converts phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine synthesis in the endoplasmic reticulum, and which acts a nuclear transcriptional coactivator for PPARGC1A/PPARA, modulating lipid metabolism-related gene expression.

Molecular pathology
LPIN2 mutations may cause lipodystrophy.
References in periodicals archive ?
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.