lipid raft

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lipid raft

(lip'id raft),
Detergent-insoluble raft microdomains that are enriched in sphingolipids and cholesterol, found in the plasma membrane, late secretory pathway, and endosomal compartments.
Farlex Partner Medical Dictionary © Farlex 2012

lipid raft

A tiny cholesterol-rich region on a cell membrane that helps selected molecules enter the cytoplasm.
Synonym: lipid domain
See also: raft
Medical Dictionary, © 2009 Farlex and Partners
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References in periodicals archive ?
Vasselon et al., "Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts," The Journal of Immunology, vol.
Wildtype mouse astrocytes secrete apoE as apoE/HDL with densities of 1.08-1.12 g/mL, whereas the astrocytes prepared from ABCA1-KO mice secrete apoE as insufficiently lipidated HDL with higher density (d = 1.12-1.17 g/mL), suggesting that the lipidation of apoE depends on the function of ABCA1 in the membrane lipid rafts of astrocytes [39].
[12] established that enhanced ceramide levels increase the number of NMDA subtypes of ionotropic glutamate receptors in lipid rafts of hippocampal synapses.
1990) where it acts through lipid rafts (Bari et al.
At the plasma membrane (PM), SLs, together with cholesterol, saturated phospholipids, and a specific pool of proteins, form macromolecular complexes that are conventionally defined lipid rafts [17, 18].
Plasma membranes are organized in (dynamic) microdomains termed lipid rafts. They play a key role in many biological processes, such as modulating a broad range of signalling cascades [108-110].
Another mechanism whereby lupus T cells exhibit a lower threshold of activation is the presence of preaggregated lipid rafts on their cell membrane [24].
"Too much cholesterol increases the abundance of lipid rafts, areas in the plasma membrane where surface receptors initiate signaling events leading to angiogenesis," Miller said.
The cell surfaces of macrophage and dendritic cells express costimulatory molecules, which are required for stimulation of the adaptive cellular immune system, and lipid rafts, which are microdomains that contain high concentrations of cholesterol, sphingolipids, and proteins integral to signaling, protein transport, and adhesion [36, 37].
reported that MVP was rapidly recruited to lipid rafts when human lung epithelial cells were infected with Pseudomonas aeruginosa?
Background and Significance: Lipid rafts are cholesterol rich membrane microdomains that bring innate immune receptors like Toll like receptor (TLR) together with signaling molecules like Src family tyrosine kinases to transmit the extracellular events into the cytoplasmic cascade of signaling proteins activation.