On the other hand, the inhibitory effect of compounds in categories C and F, which have low or no radical scavenging ability, were suggested to be due to another mechanism, such as chelation of [Fe.sup.2+] or prevention of interaction of [Fe.sup.2+] with the lipid membranes
. To obtain information about the mechanism of the compounds in categories C and F, we examined the effects of KT133 on the absorbance spectra, with or without ADP/[Fe.sup.2+].
It is known that lipid membranes
can promote hIAPP aggregation .
The "honey pot" protocells have a core of nanoporous silica wrapped in a lipid membrane
like a normal cell.
Orientation of hIAPP Aggregates at Lipid Membrane
Corresponding studies carried out on the anionic lipid raft membrane (DOPC/DOPG/DPPC/DPPG/chol, 15 : 10 : 40 : 10 : 25) showed an even more accelerated kinetics than for the aggregation in the presence of the homogeneous anionic lipid membrane
. Complementary ATR-FTIR studies revealed a slower aggregation kinetics of hIAPP in the presence of the neutral heterogeneous membrane compared to the scenario with 30% anionic membrane.
Embedded in a lipid membrane
, the system absorbs light and uses the energy to pump protons across the membrane, creating an unequal distribution between the sides.
Focused on a lipid membrane
, a laser beam's electromagnetic field induces molecular changes that tighten the membrane, increasing internal pressure.
"The more mobile molecules correlated with lipid interaction," Evers says, meaning the halothane molecules pooled in the lipid membrane
could tumble freely.