lipid hypothesis


Also found in: Wikipedia.

lipid hypothesis

Cardiology A widely accepted postulate that hyperlipidemia–eg, cholesterol, and to a lesser degree, other lipids in the circulation is responsible for CAD, the major cause of death in the US, levels which, when altered by dietary or pharmacologic manipulation, ↓ risk of ASHD-related morbidity. Cf Lipid theory.
References in periodicals archive ?
The classic lipid hypothesis of cardiovascular disease holds that dietary saturated fat raises blood cholesterol, in turn accelerating atherosclerosis and resultant coronary heart disease.
the lipid hypothesis, wilts upon close scrutiny, as is also the case with the diet-heart hypothesis, which indicts saturated fat along with cholesterol for causing atherosclerosis.
The lipid hypothesis that there is benefit from low density lipoprotein cholesterol (LDL-C) reduction was well established in the mid-1980s with publication of results from the Lipid Research Clinics Coronary Primary Prevention Trial (LRC-PPT).
Keys nevertheless persisted in promoting the lipid hypothesis and, as a member of the American Heart Association's nutrition advisory committee, got his theory incorporated into the organization's dietary recommendations, where it has remained ever since.
Rather than questioning the lipid hypothesis, we should be treating those in need earlier and more aggressively.
The lipid hypothesis has many detractors, and research has placed its validity in question.
The most detrimental effect of the Lipid Hypothesis has been the notion that somehow cholesterol is the enemy.
The lipid hypothesis that dominated American diets for 30 years may now turn out to be total hogwash.
Pollan traces the beginnings of our present epidemic of obesity, metabolic syndrome, and diabetes to the late 1970s, when America bought into the lipid hypothesis, the theory that dietary fat is responsible for chronic disease.
In the past 50 years, a plethora of studies have led most medical scientists and clinicians to accept the lipid hypothesis as truth.
With regard to the possible causes of heart disease, the lipid hypothesis can't be reconciled with the carbohydrate hypothesis, and the theory that a deficiency of omega-3 fatty acids contributes to heart disease is at odds with the thesis that refined carbohydrates are the key.
Indeed, it is now a virtual Herculean task to challenge the lipid hypothesis of atherosclerosis/coronary heart disease, and the conclusion that lowering one's cholesterol favors life extension.