leontiasis ossea

(redirected from Lion face)

meg·a·ceph·a·ly

(meg'ă-sef'ă-lē),
A condition, either congenital or acquired, in which the head is abnormally large; usually applied to an adult cranium with a capacity of over 1450 mL.
[mega- + G. kephalē, head]
Farlex Partner Medical Dictionary © Farlex 2012

McCune-Albright syndrome

An autosomal dominant condition (OMIM:174800) due to altered regulation of cAMP, endocrinopathy (e.g., hyperthyroidism) and hypophosphatemia.

Clinical findings
Precocious puberty, polyostotic (cystic fibrous dysplasia) spontaneous fractures at young age, café-au-lait spots on skin, ovarian cysts.
 
Lab
Cyclical 4–6-week fluctuations of plasma oestrogen; afflicted young girls have decreased gonadotropins, decreased response to LH-RH; increased testosterone, increased alkaline phosphatase.
 
Molecular pathology
Defects in GNAS, which encodes a G protein that modulates various membrane signalling cascasdes, cause McCune-Albright syndrome.

Management
Aromatase inhibitor testolactone.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

leontiasis ossea

Enlargement and distortion of facial bones, giving one the appearance of a lion. It can occur as a complication of hyperparathyroidism, Paget's disease, uremia, and other conditions.
See also: leontiasis
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Suresh, from Tamil Nadu in India, developed lion face syndrome when he was 18.
It leads to bones that are weak and prone to expansion, which in turn can cause leontiasis ossea (lion face syndrome).
Left untreated, lion face syndrome can encroach on the eyes, mouth and nose, interfering with sight, breathing and the taking of food.
These include the Rolls-Royce hallmark, the lion face issued by the London Assay Office, and the '925' and lion body hallmarks - both of which guarantee the minimum 92.5% purity required for sterling silver.
Use some of the butter icing to sandwich the two chocolate cakes together with the lion face on the top.
FACTUAL Madagascan lemurs bounce through an arid forest, a three-toed sloth goes for a swim (above), a ravenous lion faces down its giraffe prey The extreme forces that shape life are captured in awe-inspiring glory in the second series of Planet Earth.