linkage mapping


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linkage mapping

Determination of how close two genes on the same chromosome are to each other. The further apart the two genes are, the more likely there is to be crossing over during meiosis.
See also: mapping
References in periodicals archive ?
We performed linkage mapping to discover genomic loci that are associated with benzene-induced chromosomal damage in reticulocytes using DO mice in the combined 100-ppm exposure groups.
This clearly illustrates the benefit of multifamily testing in linkage mapping experiments, which aids in negating the effect of a small number of markers being informative in individual families.
Numbers in bolds are primer combinations used for linkage mapping in this study.
For example, linkage mapping studies have suggested several genomic areas that may contain susceptibility genes for alcoholism.
Results reported here will provide valuable resources for further studies on genetic diversity, genetic linkage and chromosome linkage mapping of A.
Two approaches are mostly used for genetic mapping: (i) Family-based linkage mapping (ii) LD-based Association mapping (Mackay and Powell, 2007).
Segregation distortion has been recognized through linkage mapping studies in many plants since the advent of molecular markers.
Microsatellites are highly polymorphic and have become one of the most useful tools for population genetic studies, linkage mapping, parentage determination and QTL analysis.
Results indicate that (a) a large number of ESTs isolated from this cDNA library are similar to cytoskeleton mRNAs anal may reflect a normal pathway of the cellular response after im infection with WSSV, and (b) primers flanking single or multiple SSRs with three or more repeats from shrimp ESTs could be an efficient approach to develop polymorphic markers useful for linkage mapping.
However, Hackett and Broadfoot (2003) studied the effects of segregation distortion on linkage mapping and found minimal effects on marker order or map length.