paraneoplastic limbic encephalitis

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paraneoplastic limbic encephalitis

Abbreviation: PNLE
A brain disorder occurring in some patients with cancer, characterized by the rapid onset of memory loss, often with temporal lobe disease, seizures, delirium, or disturbances of mood. Patients with PNLE often have antibodies against tumor antigens that also react with nerve cell antigens. In some patients the neurological disorder improves after treatment of the responsible tumor.
See also: encephalitis
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Recently, also in retrospect, VSBV-1 was shown to be responsible for fatal limbic encephalitis in a zoo animal caretaker after contact with an exotic Prevost's squirrel (Callosciurus prevostii) in northern Germany (2).
Autoimmune limbic encephalitis is frequently recognized as a cause of subacute encephalopathy with seizures.
Memory lost, memory regained:Neuropsychological findings and neuroimaging in two cases of paraneoplastic limbic encephalitis with radically different outcomes.
Paraneoplastic and nonparaneoplastic limbic encephalitis can also present with RPD and behavior and movement disturbances.
Morgan was then diagnosed with Sero-negative Limbic encephalitis with bilateral temporal lobe involvement - a very rare and cruel condition affecting a small number of people each year.
Authors wondered if HSV could trigger the autoantibody secretion and by the way be responsible of limbic encephalitis, first described as paraneoplasic presentation by Dalmau (26).
Anti-leucine-rich glioma-inactivated 1 (LGI1) limbic encephalitis is caused by antibodies against the LGI1 element of the voltage-gated potassium channel (VGKC) complex [20].
Neurologic complications of RP are rare in general; in the literature limbic encephalitis was reported and the patient presented with cognitive dysfunction [4].
The anti-GAD antibodies typically cause a form of autoimmune encephalitis with classic temporal lobe lesions on MR imaging with the expected clinical findings of limbic encephalitis, and/or additional features of stiff person syndrome with early and prominent development of seizures [6].
It has been described as the pathognomonic semiology for autoimmune limbic encephalitis (ALE) [1].
Limbic encephalitis (LE) is an autoimmune, neurological disorder characterized by confusion, memory disturbance, and seizures.