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Limb-girdle muscular dystrophy (LGMD)

This form of muscular dystrophy begins in late childhood to early adulthood and affects both men and women, causing weakness in the muscles around the hips and shoulders.
Mentioned in: Muscular Dystrophy
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
In conclusion, this study widens the phenotype of TRAPPC11 mutation related disorder and provides a conclusive case report for LGMD.
Abbreviations ALT: Atypical lipomatous tumor WDLS: Well-differentiated liposarcoma LGMD: Limb-girdle muscular dystrophy.
The only female who showed complete presence of dystrophin immunostaining of weak intensity was diagnosed as LGMD.
In a total of 32 patients (biopsy specimens) (n=23) 71.87% were diagnosed as DMD, whereas (n=10) 31.25% were diagnosed as BMD and the remaining one case (3.12%) was of LGMD.
LGMD 1B is an autosomal dominantly-inherited, slowly progressive pelvic girdle weakness with late involvement of humeral muscles and sparing of the peroneal and tibial muscles.
There are at least a dozen different forms of LGMD, and they're classified by the genetic flaws that appear to cause them (see "Known Forms of Limb-Girdle Muscular Dystrophy").
Mayur was first diagnosed as having LGMD when he was 12, forcing him to give up sport as he became weaker.
Myonexus Therapeutics is a developing treatments for limb girdle muscular dystrophies (LGMDs) based on research at Nationwide Children's Hospital.
Biotherapeutics company aTyr Pharma Inc (NasdaqGS:LIFE) disclosed on Friday the receipt of the European Medicines Agency (EMA) orphan drug designation for Resolaris for the treatment of limb girdle muscular dystrophy (LGMD) patients.
For example, testing for the dysferlin (DYSF) [4] gene for a subtype of limb girdle muscular dystrophy (LGMD) [5] was performed only on patients presenting with muscle weakness, and all other tests ordered along with DYSF also fell into the "muscle disorder" category.
In contrast to the American and European population, LGMD2A seems not to be the most popular subtype of LGMD in China.