Leydig cell tumour

Leydig cell tumour

An uncommon gonadal tumour, which is functionally active and secretes steroids, usually testosterone; benign and malignant Leydig cell tumours are separated based on histologic features.

Clinical findings
Usually affects males, with a bimodal peak at age 5–10 and between 30 and 60. Childhood presentation is classically associated with precocious puberty in males, due to testosterone secretion by the tumour. One-third of female patients with Leydig cell tumours develop progressive masculinisation, preceded by anovulation, oligomenorrhoea, amenorrhoea and defeminisation, and often acne and hirsutism, voice deepening, clitoromegaly, hair recession, and increased muscle mass.

Malignant features
> 5 cm, infiltration, vascular invasion, necrosis,  pleomorphism.
References in periodicals archive ?
Benign lesions that were histopathologically diagnosed included mature teratoma, adenomatoid tumour, granulomatous orchitis, chronic orchitis, epididim-orchitis, epididymal cyst, Leydig cell tumour, Sertoli cell tumour, fibrous pseudotumour, tunica albugenia cyst, epidermal cyst, leiomyoma, fibroma, juvenile granulosa cell tumour, granulomatous epididymitis, and microlithiasis with epididymal abscess.
Histopathological examination revealed a Sertoli leydig cell tumour.
The histopathology report came out to be well differentiated Sertoli leydig cell tumour.
DISCUSSION: Our case is a low grade Sertoli leydig cell tumour (SLCT) presenting in a young female.
RiofrioT, Bahubeshi A, Kanelloupolou C , Hamel N: DICER 1 mutation in familial multinodular goiter with and without sertoli leydig cell tumour JAMA 2011, Jan 5 ;305(1) 68-77
A differential diagnosis of this tumour includes a steroid cell tumour (stromal luteoma, Leydig cell tumour, steroid cell tumour, not otherwise specified, dysgerminoma, and a clear cell variant of struma ovarii.
Of these 36( 76 %)were granulosa cell tumour (adult33, juvenile3), 7 were labeled as sertoli leydig cell tumours (15%), 3 as thecoma/ fibroma group (7%)and only one case was labeled as microcystic stromal tumour of the ovary (2%).
Of these 36( 76 %)were granulosa cell tumours (adult 33, juvenile 3), 7 were labeled as sertoli leydig cell tumours (15%), 3 as thecoma/ fibroma group (7%) and only one case was labeled as microcystic stromal tumour of the ovary (2%).
Thirty four out of 36 Granulosa cell tumours (32 out of 33 adult and 2 out 3 juvenile granulosa cell tumours), all cases of sertoli leydig cell tumours, three of fibroma/ thecoma cases and one case of microcystic stromal tumour.
Neuroendocrine characteristics of human Leydig cell tumours.
1] The development of a neoplasm in an ectopic adrenal deposit is uncommon, yet phaeochromocytoma and Leydig cell tumours have been reported.
Osseous metaplasia has been documented in well differentiated Sertoli, Leydig cell tumours, mucinous cystadenoma, fibromas and serous papillary cystadenocarcinoma [8,9].