Leydig cell tumour
Leydig cell tumourAn uncommon gonadal tumour, which is functionally active and secretes steroids, usually testosterone; benign and malignant Leydig cell tumours are separated based on histologic features.
Usually affects males, with a bimodal peak at age 5–10 and between 30 and 60. Childhood presentation is classically associated with precocious puberty in males, due to testosterone secretion by the tumour. One-third of female patients with Leydig cell tumours develop progressive masculinisation, preceded by anovulation, oligomenorrhoea, amenorrhoea and defeminisation, and often acne and hirsutism, voice deepening, clitoromegaly, hair recession, and increased muscle mass.
> 5 cm, infiltration, vascular invasion, necrosis, pleomorphism.