Leydig cell tumour

Leydig cell tumour

An uncommon gonadal tumour, which is functionally active and secretes steroids, usually testosterone; benign and malignant Leydig cell tumours are separated based on histologic features.

Clinical findings
Usually affects males, with a bimodal peak at age 5–10 and between 30 and 60. Childhood presentation is classically associated with precocious puberty in males, due to testosterone secretion by the tumour. One-third of female patients with Leydig cell tumours develop progressive masculinisation, preceded by anovulation, oligomenorrhoea, amenorrhoea and defeminisation, and often acne and hirsutism, voice deepening, clitoromegaly, hair recession, and increased muscle mass.

Malignant features
> 5 cm, infiltration, vascular invasion, necrosis,  pleomorphism.
References in periodicals archive ?
A differential diagnosis of this tumour includes a steroid cell tumour (stromal luteoma, Leydig cell tumour, steroid cell tumour, not otherwise specified, dysgerminoma, and a clear cell variant of struma ovarii.
1] The development of a neoplasm in an ectopic adrenal deposit is uncommon, yet phaeochromocytoma and Leydig cell tumours have been reported.
Neuroendocrine characteristics of human Leydig cell tumours.