Leydig cell hyperplasia

Leydig cell hyperplasia

A condition characterised by diffuse autonomous hyperfunction of hyperplastic Leydig cells.
 
Aetiology
Activating mutation of LHCGR, the luteinising hormone receptor gene.
 
Clinical findings
Precocious puberty.
 
Management
Orchidectomy.

Leydig cell hyperplasia

Endocrinology Autonomous hyperplasia and hyperfunction of Leydig cells Etiology Activating mutation of LH receptor gene Clinical Precocious puberty Management Orchidectomy
References in periodicals archive ?
Farih, "Leydig cell hyperplasia revealed by gynecomastia," Reviews in Urology, vol.
[5] demonstrated that fetuses with PBS had marked Leydig cell hyperplasia in contrast to the other groups.
Histopathology revealed--mixed germ cell tumor, predominantly seminoma with focal areas of yolk sac tumor in the right gonad while the left gonad showed testicular tissue comprising seminiferous tubules with arrest in spermatogenesis and leydig cell hyperplasia. Paraaortic lymph node showed metastasis by mixed germ cell tumor while the omentum showed no evidence of metastasis.
Conventional LCT (ie, tumors in which the cells are round to polygonal with eosinophilic cytoplasm, arranged in sheets, nests, or trabecula) must be differentiated from Leydig cell hyperplasia, granular cell tumor, malakoplakia, the testicular nodules of adrenogenital syndrome, and other tumors of the testis (Table).