Leydig cell hyperplasia

Leydig cell hyperplasia

A condition characterised by diffuse autonomous hyperfunction of hyperplastic Leydig cells.
 
Aetiology
Activating mutation of LHCGR, the luteinising hormone receptor gene.
 
Clinical findings
Precocious puberty.
 
Management
Orchidectomy.

Leydig cell hyperplasia

Endocrinology Autonomous hyperplasia and hyperfunction of Leydig cells Etiology Activating mutation of LH receptor gene Clinical Precocious puberty Management Orchidectomy
References in periodicals archive ?
Histopathology revealed--mixed germ cell tumor, predominantly seminoma with focal areas of yolk sac tumor in the right gonad while the left gonad showed testicular tissue comprising seminiferous tubules with arrest in spermatogenesis and leydig cell hyperplasia.
Leydig cell tumor differs from Leydig cell hyperplasia by being solitary, whereas nodular Leydig cell hyperplasia is characteristically multifocal.
In mice at a dose of 25 mg/kg/day (23 times the human exposure, estimated) and in rats at a dose of > or =40 mg/kg/day (39 times the human exposure) an increase in the incidence of Leydig cell hyperplasia was observed.