A novel inactivating mutation of the LH/chorionic gonadotrophin receptor with impaired membrane trafficking leading to Leydig cell
hypoplasia type 1.
In the present study, although the consumption of BD1/2 elevated the number of Leydig cells
, in line with the increased testosterone level they produced, the expected volume increase in the interstitial tissue was not observed.
Therefore, the increase in intracellular calcium concentration ([[[Ca.sup.2+]].sub.i]) due to P2X receptor activation is one of the processes that can enhance steroidogenesis in Leydig cells
. On the other hand, nitric oxide (NO) has also been taken as a global modulator of this process.
Sertoli, and certain types of germs cells (Figure 7C, Table 3) The intensity of CYP19 immunostaining became notably weaken in Leydig cell
of the testis treated with m low-dose ND for two weeks, while the immunoreactivity of CYP19 in Sertoli and germ cells was not visibly changed with a low-dose ND treatment for 2 weeks (Figure 7C, Table 3).
He et al., "Up-regulation of NDRG2 through nuclear factor-kappa B is required for Leydig cell
apoptosis in both human and murine infertile testes," Biochimica et Biophysica Acta--Molecular Basis of Disease, vol.
Quantitative analysis documented a significantly smaller number (p = 0.0002) of Leydig cells
in the PBS testes (mean = 67.03% and SD = 3.697), when compared to the control group (mean = 90.1% and SD = 2.986) (Figure 2).
Many studies have demonstrated that LOH is closely linked to a deficiency in serum testosterone levels [1-3] because the total number of Leydig cells
, which are the main source of testosterone in middle-aged men, decreases to about a half of that seen in young men [4, 5].
Testosterone is synthesized from cholesterol, which is stored in cytoplasmic lipid droplets that can be synthesized de novo from acetyl-coenzyme within the Leydig cells
or that can be uptaken by cells through endocytosis of low-density lipoproteins .
When Examination the transverse -sections of testicular tissue of male mice treatment dose(T1A) observed disintegration and spacing Seminiferous tubules from each other within the testis sector(Figs 3a,b), alienation in epithelial germ cells for Some of these tubules(Figs 3b,c,d), inflammatory infiltration(Figs 3a,e), sertoli cells (S.C) complete dissolution and Laceration links between sertoli cells and some of the spermatocytes with the advent of large vacuolization between spermatocytes (Figs 3a,b,e), emergence of a local death in some areas(Figs 3d,e),decrease in the number of leydig cells
(L.C) with taken irregular shapes also its nuclei began to lose its natural shape and take different forms(Figs 3a,b,c,d), sperms scarceness in a lot of cavities Seminiferous tubules(Figs 3a,e).
of % Overall cases % I Sex cord /stromal tumor 2 100 1.73 1 Leydig cell
tumor 2 100 1.73 II.
However; Sertoli and Leydig cell
concentrations were not affected by PJ administration.
Percentage area of interstitial cells in relation to seminiferous tubules of each testis was measured at 200X while leydig cell
diameter at 1000X using Nikon Optiphot 2 microscope, Japan.