Leydig cell


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Related to Leydig cell: spermatogenesis, Leydig cell tumor

Leydig cell

The testosterone-secreting cell of the testis which is located in clusters in the interstitium between the seminiferous tubules. Leydig cells are large and have centrally located nuclei, eosinophilic cytoplasm and numerous lipid-filled cytoplasmic vacuoles.

Function
Male sexual differentiation, pubertal androgenisation, support for fertility.
 
Physiology 
Secrete testosterone, androstenedione and dehydroepiandrosterone (DHEA) in response to central (pituitary) stimulation by luteinising hormone, which activates cholesterol desmolase.

Leydig cell

(lī′dĭg)
[Franz von Leydig, Ger. anatomist, 1821–1908]
One of the interstitial cells in the testes that produce testosterone.
References in periodicals archive ?
After this, the individual volume of the Leydig cell was determined with mathematical models, using the values of nuclear diameter and proportion in the testis.
Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis.
In tubular compartment were measured the tunica propria, the seminiferous epithelium and the lumen; while in the intertubular compartment were analyzed Leydig cells, blood and lymph vessels, mast cells and other components such as cells and fibers of connective tissue.
Together with Leydig cells, adult rat germ cells are able to express P45Oaroni mRNA, which is translated as a biologically active enzyme involved in estrogen production.
Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroido- genie enzyme gene expression in rat Leydig cells.
The name FSH and LH is based on the action of hormones in females whereas in males FSH stimulates the Sertoli cells of testis and thereby promotes spermatogenesis and LH stimulates the Leydig cells to secrete testosterone.
Leydig cell hyperplasia and adenoma formation: mechanisms and relevance to humans.
1) It is highly unusual for Leydig cell tumors to present prior to 2 years of age.
The involvement of triiodothyronine (T3) in the control of sertoli cell proliferation and functional maturation is widely accepted, as well as its role in postnatal leydig cell differentiation and steroidogenesis.
The authors of this study conclude that a hypogonadal state or Leydig cell failure can be induced with zinc deficiency altering testicular steroidogenesis.
Embryologically, it has been speculated that the peritubular fibroblasts contribute to trigger mechanisms that initiate fetal Leydig cell differentiation via local growth factors from the endothelial cells (Skinner, 1991).
To ensure that inherent toxicity of our tested chemicals and their mixtures did not induce a downturn in testosterone synthesis, thereby confounding any genuine anti-androgenic effects, we assessed the functional integrity of the testosterone-producing Leydig cell population by immunolabeling of cytochrome P450 (CYP11A1), a key enzyme of the androgen biosynthesis pathway.