Lewy bodies


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.

Le·wy bod·ies

(lā'vē),
intracytoplasmic neuronal inclusion; bodies especially noted in pigmented brainstem neurons and seen in Parkinson disease, diffuse Lewy body disease, occasionally in Alzheimer disease, and rarely in healthy old people.

Lewy bodies

[lā′wē, lo̅o̅′ē]
Etymology: Frederick H. Lewy, German neurologist, 1885-1950
concentric spheres found inside vacuoles in midbrain and brainstem neurons of patients with idiopathic parkinsonism, Alzheimer's disease, and other neurodegenerative conditions.
enlarge picture
Lewy body in the substantia nigra

Lewy bodies

Abnormal intracellular proteins that occur in the nerve cells of the cerebral cortex, basal ganglia and pigmented brainstem neurons, causing Parkinsonism. If present in large quantities they as associated with dementia (diffuse Lewy body disease). (Frederic H. Lewy 1885–1950, US neurologist of German origin).

Lewy,

(Lewey), Frederic H., German neurologist in the U.S., 1885-1950.
Lewy bodies - intracytoplasmic inclusion bodies especially noted in pigmented brainstem neurons and seen in Parkinson disease.

disease

pathogenic entity characterized by an identifiable aetiological agent, group of signs and symptoms and/or consistent anatomical alterations; see syndrome
References in periodicals archive ?
Identifying people with mild cognitive impairment at risk for dementia with Lewy bodies is critical for early interventions," says the study's lead author Kejal Kantarci, MD, a Mayo Clinic radiologist.
Since then, it has been widely believed that only rare Lewy bodies are found in the cerebral cortex.
Dementia with Lewy bodies (DLB) and Parkinson disease with dementia (PDD) are the most common dementia types after AD, with a worldwide incidence rate of 15%-20% among dementia diagnoses (Aarsland et al, 2009; Ballard et al, 2010; Reilly, Rodriguez, Lamy, & Neils-Strunjas, 2010; Sauer, Ffytche, Ballard, Brown, & Howard, 2006).
Cholinesterase inhibitors have shown some symptomatic benefit for dementia with Lewy bodies, including for hallucinations
The mice used in this study over-express alpha-Synuclein, the protein that builds up in Lewy bodies in Parkinson's disease and dementia patients and which is found in many other neurodegenerative diseases.
After six months, Lewy bodies were found inside these cells.
The investigators used both clinical diagnoses and histopathology to identify patients as having Alzheimer's disease without Lewy bodies (244), Alzheimer's with Lewy bodies (224), pure Lewy body dementia (91), or Parkinson's dementia without Alzheimer's neuropathology (81).
Gross infarcts attributed for only 2 percent, and Lewy bodies accounted for 8 percent.
PhD student Ruth Cromarty, is beginning a three-year project at Newcastle University to unravel the symptoms of dementia with Lewy bodies, the third most common cause of the illness.
Webster Ross of the University of Hawaii in Honolulu and HAAS colleagues have assessed the relationship among these four factors and not only PD but the presence of Lewy bodies in the brain as well.
Dimentia with Lewy bodies and Parkinson's disease dementia/edited by John O'Brien, Ian McKeith, David Ames and Edmon Chiu.
Associated with this neuronal loss is the presence of large eosinophilic inclusions, called Lewy bodies, within the remaining pigmented neurons, made up of a series of proteins, including neurofilaments, [alpha]-synuclein fibrils, ubiquitin, parkin, and proteasomal elements.