Treatment of dementia with Lewy bodies
and Parkinson's disease dementia.
RVT-101 in Dementia with Lewy Bodies
Program Initiation Axovant plans to initiate a 24-week Phase 2b study of RVT-101 as a potential treatment for DLB.
Injectable (ioflupane [123I] injection) "DaTSCAN") is a brain imaging agent to be used in evaluating the distribution of presynaptic dopamine transporters in the striatal region of the brain for diagnosing Parkinson's Syndrome and dementia with Lewy bodies
The mice used in this study over-express alpha-Synuclein, the protein that builds up in Lewy bodies
in Parkinson's disease and dementia patients and which is found in many other neurodegenerative diseases.
If the amygdala has Lewy bodies
, additional [alpha]-synuclein immunostaining should be performed on anterior cingulate gyrus, and if Lewy bodies
are seen in the cingulate, then additional [alpha]-synuclein immunostaining should be performed on frontal, temporal, and parietal neocortex for grading of the Lewy body pathology.
The ApoE e4 genotype was present in 7% of the control subjects, 19% of patients with Parkinson's dementia, 32% of those with pure Lewy body dementia, 41% of those with Alzheimer's and Lewy bodies
, and 38% of those with pure Alzheimer's.
Specifically, the guidelines, which were last issued in 2007(2), note that SPECT "may increase diagnostic confidence in the evaluation of dementia," adding that dopaminergic SPECT imaging with DaTSCAN is useful in differentiating AD from dementia with Lewy bodies
(DLB)(1), a neurological condition that is similar to AD in that it results from the death of nerve cells in the brain.
Rats with these lesions had cytoplasmic inclusions containing [alpha]-synuclein in the nigral neurons, which resembled the pale body precursors to Lewy bodies
found in humans with PD.
in Jacksonville, who has developed a way to form Lewy bodies
in cultured nerve cells.
Dementia with Lewy bodies
- also known as Lewy body dementia - is a type of dementia that shares symptoms with both Alzheimer's disease and Parkinson's disease, and may account for around 10% of all cases of the disease.
The investigators adjusted their models for other features found in the brains of patients with Alzheimer's disease, such as the presence of amyloid-beta plaques and Lewy bodies
World's First Treatment For Both Alzheimer's Disease And Dementia With Lewy Bodies