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intracytoplasmic neuronal inclusion; bodies especially noted in pigmented brainstem neurons and seen in Parkinson disease, diffuse Lewy body disease, occasionally in Alzheimer disease, and rarely in healthy old people.
Etymology: Frederick H. Lewy, German neurologist, 1885-1950
concentric spheres found inside vacuoles in midbrain and brainstem neurons of patients with idiopathic parkinsonism, Alzheimer's disease, and other neurodegenerative conditions.
Lewy bodiesAbnormal intracellular proteins that occur in the nerve cells of the cerebral cortex, basal ganglia and pigmented brainstem neurons, causing Parkinsonism. If present in large quantities they as associated with dementia (diffuse Lewy body disease). (Frederic H. Lewy 1885–1950, US neurologist of German origin).
Lewy,(Lewey), Frederic H., German neurologist in the U.S., 1885-1950.
Lewy bodies - intracytoplasmic inclusion bodies especially noted in pigmented brainstem neurons and seen in Parkinson disease.