Lewy bodies


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Le·wy bod·ies

(lā'vē),
intracytoplasmic neuronal inclusion; bodies especially noted in pigmented brainstem neurons and seen in Parkinson disease, diffuse Lewy body disease, occasionally in Alzheimer disease, and rarely in healthy old people.
Farlex Partner Medical Dictionary © Farlex 2012

Lewy bodies

Abnormal intracellular proteins that occur in the nerve cells of the cerebral cortex, basal ganglia and pigmented brainstem neurons, causing Parkinsonism. If present in large quantities they as associated with dementia (diffuse Lewy body disease). (Frederic H. Lewy 1885–1950, US neurologist of German origin).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Lewy,

(Lewey), Frederic H., German neurologist in the U.S., 1885-1950.
Lewy bodies - intracytoplasmic inclusion bodies especially noted in pigmented brainstem neurons and seen in Parkinson disease.
Medical Eponyms © Farlex 2012
References in periodicals archive ?
Ross and his colleagues also have determined that there is prolonged reaction time with the presence of incidental Lewy bodies. Reaction time was assessed for the HAAS cohort using a computerized reaction time test (the 3RT).
Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study.
Consensus Guidelines for the Clinical and Pathologic diagnosis of Dementia with Lewy Bodies. Report of the Consortium on DLB International Workshop.
Kosaka et al., "Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop," Neurology, vol.
"Identifying people with mild cognitive impairment at risk for dementia with Lewy bodies is critical for early interventions," says the study's lead author Kejal Kantarci, MD, a Mayo Clinic radiologist.
It can appear three decades or more before a diagnosis of dementia with Lewy bodies is made in males, the researchers said.
Although it is possible that both of the diseases may lie on a continuum of a single disease that begins with ADHD manifested in childhood and continues into adulthood as dementia with Lewy bodies "when neuronal loss and gliosis in the substantia nigra, locus coeruleus, and nucleus basalis of Meynert occur," the authors doubted that this hypothesis could be accurate because low dopamine levels in ADHD are not initially associated with Parkinsonlike or DLB symptoms.
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are both dementias indicated by cognitive decline inappropriate to age that interfere with normal tasks of daily living.
On post-mortem examination, neurofibrilliary tangles are a characteristic of PSP in contrast to the Lewy bodies of IPD.[1] In addition, in PSP there is a greater loss of dopamine in the caudate than the putamen, the reverse being true in IPD.
[USPRwire, Wed Nov 21 2018] Lewy body dementia (LBD), also known as dementia with Lewy bodies, is the second most cause of progressive dementia in the U.S., following Alzheimer's disease.
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia after Alzheimer's disease (AD) in people over 65 years of age.
They included AD, Lewy bodies, hippocampal sclerosis, microinfarcts, and low brain weight (see box, following page).