Lewis Blood Group

Le·wis Blood Group

, Le Blood Group (lū'wis blŭd grūp),
See Blood Groups Appendix.
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[11] demonstrated that the association of the Lewis blood group with infertility in among groups was not statistically different, but Khan et al.
Ten per cent of the white population lack the Lewis blood group antigen and are unable to produce CA 19-9, even in the presence of malignant disease.M High levels of CA 19-9 were subsequently reported in other gastrointestinal malignancies, including pancreas, bile duct, oesophageal and gastric cancer, as well as non-gastrointestinal tumours.[5] Increased levels have also been observed in non-malignant causes of cholestatic jaundice, particularly chronic pancreatitis and choledocholithiasis.
Recently, molecular genetic studies were carried out to determine the role of the H, Se and Le genes in the expression of H antigen in secretions and Lewis blood group antigen on erythrocytes.
Daniels (Bristol Institute for Transfusion Services) and Bromilow (DiaMed AG) describe the ABO, Rh, Kell, Duffy, Kidd, MNS, Diego, and Lewis blood group systems, and explain the clinical significance of blood group antibodies causing hemolytic transfusion reaction and hemolytic disease of the fetus and newborn.
The investigators compared the risk of cardiovascular mortality among men with different Lewis blood group types.
The kappa measurement of agreement between conventional blood grouping of erythrocytes and the PCR genotyping method was calculated as 0.81, which indicates that there is good agreement between the two methods of determining the Lewis blood group status.
The kappa measurement of agreement was calculated as 0.96, which indicates that there is good agreement between the two methods of determining the Lewis blood group status in secretor-positive individuals.
Differential tissue expression of the Lewis blood group antigens: enzymatic, immunohistologic, and immunochemical evidence for Lewis a and b antigen expression in Le(a-b-) individuals.
A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group all/1,4)fucosyltransferase.
Similarly, Lewis blood groups were determined according to tube method.

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