aminolevulinic acid

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aminolevulinic acid

 (ALA) [ah-me″no-lev″u-lin´ik]
δ-aminolevulinic acid; a precursor of porphyrins and hemoglobin; serum levels of this acid are elevated in lead poisoning and urinary levels are increased in some porphyrias. The hydrochloride salt is used as a topical photosensitizer in the treatment of nonhyperkeratotic actinic keratoses.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

aminolevulinic acid

Oncology A drug used in photodynamic therapy which is absorbed by tumor cells and activated when exposed to light, killing the cells. See Photodynamic therapy.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
District Court for the District of Massachusetts alleging trade secret misappropriation and patent infringement of DUSA's photodynamic therapy patents, covering DUSA's product LEVULAN KERASTICK (aminolevulinic acid HCl) for topical solution, 20 percent used with DUSA's BLU-U Blue Light Photodynamic Therapy Illuminator.
She cited a study recently published from South Korea in which 46 patients with facial acne applied a much lower concentration of ALA, a new variant of 5-aminolevulinate ester (1.5% 3-butenyl ALA-bu gel), compared with the 20% concentration in the Levulan Kerastick available in the United States (J Dermatol.
A one-time application of 5-aminolevulinic acid (Levulan Kerastick), followed by exposure to blue light, resulted in complete AK clearing in 72% of patients after 12 weeks, versus 11% with vehicle alone.