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vardenafil hydrochloride


Pharmacologic class: Phosphodiesterase-5 (PDE5) inhibitor

Therapeutic class: Erectile dysfunction agent

Pregnancy risk category B


Selectively blocks PDE5, which neutralizes cyclic guanosine monophosphate, resulting in enhanced erectile function


Tablets: 2.5 mg, 5 mg, 10 mg, 20 mg

Indications and dosages

Erectile dysfunction

Adult males: 10 or 20 mg P.O. approximately 1 hour before anticipated sexual activity. Maximum dosing frequency is once daily.

Dosage adjustment

• Patients older than age 65

• Concurrent use of CYP450-3A4 inhibitors

• Concurrent HIV therapy (except highly active antiretroviral therapy)


• Hypersensitivity to drug

• Concurrent use of nitrates or nitrate patches to treat angina

• Concurrent use of alpha-adrenergic blockers


Use cautiously in:

• cardiovascular disease, retinitis pigmentosa, hepatic or renal impairment, reduced hepatic blood flow

• patients at increased risk for priapism (as from sickle-cell disease, leukemia, multiple myeloma, polycythemia, or history of priapism).


• Advise patient not to take more than one tablet daily.

Adverse reactions

CNS: headache

CV: hypotension

EENT: blurred vision, altered color perception, light sensitivity, rhinitis

GI: dyspepsia

Skin: flushing

Other: flulike symptoms


Drug-drug. Alpha-adrenergic blockers, nitrates: hypotension

Erythromycin, itraconazole, ketoconazole, protease inhibitors: increased vardenafil blood level

Drug-diagnostic tests. Creatine kinase: increased level

Patient monitoring

• Monitor blood pressure and heart rate, particularly if patient has cardiovascular disease.

Patient teaching

• Tell patient he may take with or without food.

• Instruct patient to take one tablet about 1 hour before anticipated sexual activity. Caution him not to take more than one tablet daily.

• Instruct patient to promptly contact prescriber if erection lasts more than 4 hours, because irreversible damage to penis may occur.

• Caution patient not to take nitrates. Tell him to inform prescriber of other drugs he's taking.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A trademark for the drug vardenafil hydrochloride.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
A cGMP-specific phosphodiesterase type 5 inhibitor used to manage erectile dysfunction, taken ±1 hour before anticipated sexual activity; it is apparently effective for diabetics
Adverse effects Headache, dyspepsia, nausea, rhinitis
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


A brand name for VARDENAFIL.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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The way we're bombarded on TV and radio every five minutes with ads for Viagra, Cialis, Levitra and Enzyte, to name a few?
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There were no cases reported among users of Levitra, the third impotence drug.
Steve King (R-Iowa), who told Roll Call that he opposes Medicare funding for Viagra and Levitra. "Is it the government's business to provide those funds and resources so that old men can have sex when they want?" the congressman asked, adding--without irony--that this "kind of growth in government was never envisioned by our Founding Fathers."