insulin detemir

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insulin detemir

(in-su-lin de-te-mir) ,


(trade name)


Therapeutic: antidiabetics
Pharmacologic: pancreatics
Pregnancy Category: B


Control of hyperglycemia in patients with type 1 (IDDM) and type 2 (NIDDM) diabetes mellitus.


Lower blood glucose by :
  • stimulating glucose uptake in skeletal muscle and fat,
  • inhibiting hepatic glucose production.
Other actions of insulin:
  • inhibition of lipolysis and proteolysis,
  • enhanced protein synthesis.

Therapeutic effects

Control of hyperglycemia in diabetic patients.


Absorption: Delayed and prolonged.
Distribution: Identical to endogenous insulin.
Metabolism and Excretion: Metabolized by liver, spleen, kidney, and muscle.
Half-life: 5–7 hr (dose-dependent).

Time/action profile ( hypoglycemic effect)

Subcut3–4 hr3–14 hr†6–24 hr‡
†Small amounts of insulin detemir are slowly released resulting in a relatively constant effect over time.‡Duration is dose dependent; duration increases as dose increases.


Contraindicated in: Hypoglycemia; Allergy or hypersensitivity to a particular type of insulin, preservatives, or other additives.
Use Cautiously in: Stress and infection may temporarily alter insulin requirements; Renal/hepatic impairment (may ↓ insulin requirements); Concomitant use with pioglitazone or rosiglitazone (↑ risk of fluid retention and worsening HF) Obstetric: Pregnancy may temporarily alter insulin requirements; Pediatric: Children <2 yr (safety not established)..

Adverse Reactions/Side Effects


  • hypoglycemia (life-threatening)


  • lipodystrophy
  • pruritis
  • erythema
  • swelling


  • allergic reactions including anaphylaxis (life-threatening)


Drug-Drug interaction

Beta blockers, clonidine, and reserpine may mask some of the signs and symptoms of hypoglycemia.Corticosteroids, thyroid supplements, estrogens, isoniazid, niacin,phenothiazines,, and rifampin may ↑ insulin requirements.Alcohol, ACE inhibitors, MAO inhibitors, octreotide, oral hypoglycemic agents, and salicylates, may ↓ insulin requirements.Concurrent use with pioglitazone or rosiglitazone may ↑ risk of fluid retention and worsening HF.Glucosamine may worsen blood glucose control.Fenugreek, chromium, and coenzyme Q-10 may produce additive hypoglycemic effects.


Dose depends on blood glucose, response, and many other factors.
Subcutaneous (Adults and Children > 2 yr) Type 2 diabetes patients who are insulin-naive–0.1–0.2 units/kg once daily in the evening (or divided into a twice daily regimen) or 10 units once daily in the evening (or divided into a twice daily regimen). Patients with type 1 or 2 diabetes receiving basal insulin or basal bolus therapy—may substitute on an equivalent unit-per-unit basis.


Solution for injection: 100 units/mL in 10–mL vials and 3–mL cartridges

Nursing implications

Nursing assessment

  • Assess patient for signs and symptoms of hypoglycemia (anxiety; restlessness; tingling in hands, feet, lips, or tongue; chills; cold sweats; confusion; cool, pale skin; difficulty in concentration; drowsiness; nightmares or trouble sleeping; excessive hunger; headache; irritability; nausea; nervousness; tachycardia; tremor; weakness; unsteady gait) and hyperglycemia (confusion, drowsiness; flushed, dry skin; fruit-like breath odor; rapid, deep breathing, polyuria; loss of appetite; nausea; vomiting; unusual thirst) periodically during therapy.
  • Monitor body weight periodically. Changes in weight may necessitate changes in insulin dose.
  • Lab Test Considerations: Monitor blood glucose every 6 hr during therapy, more frequently in ketoacidosis and times of stress. Hemoglobin A1C may be monitored every 3–6 mo to determine effectiveness.
  • Overdose is manifested by symptoms of hypoglycemia. Mild hypoglycemia may be treated by ingestion of oral glucose. Severe hypoglycemia is a life-threatening emergency; treatment consists of IV glucose, glucagon, or epinephrine. Recovery from hypoglycemia may be delayed due to the prolonged effect of subcut insulin detemir.

Potential Nursing Diagnoses

Noncompliance (Patient/Family Teaching)


  • high alert: Insulin-related medication errors have resulted in patient harm and death. Clarify ambiguous orders; do not accept orders using the abbreviation “u” for units, (can be misread as a zero or the numeral 4; has resulted in tenfold overdoses). Insulins are available in different types, strengths. Check type, dose, and expiration date with another licensed nurse. Do not interchange insulins without consulting physician or other health care professional.
  • Do not confuse Levemir (insulin detemir) with Lovenox (enoxaparin).
  • Use only insulin syringes to draw up dose. The unit markings on the insulin syringe must match the insulin’s units/mL. Special syringes for doses <50 units are available. Prior to withdrawing dose, rotate vial between palms to ensure uniform solution; do not shake.
    • high alert: Do not mix insulin detemir with any other insulin or solution, or use syringes containing any other medicinal product or residue. If giving with a short acting insulin, use separate syringes and different injection sites. Solution should be clear and colorless with no particulate matter.
    • Do not use if cloudy, discolored, or unusually viscous. Store unopened vials and cartridges of insulin detemir in the refrigerator; do not freeze. After initial use vials of insulin detemir cartridges (PenFill) or a prefilled syringe may be stored in a cool place for 42 days. Do not store in-use cartridges and pre-filled syringes in refrigerator or with needle in place. Keep away from direct heat and sunlight.
  • Subcutaneous: Rotate injection sites.
    • Administer daily insulin detemir with evening meal or at bedtime. Administer twice daily insulin detemir evening dose with evening meal, at bedtime, or 12 hrs after morning dose.
  • Not for IV administration or use with insulin pumps.

Patient/Family Teaching

  • Instruct patient on proper technique for administration. Include type of insulin, equipment (syringe, cartridge pens, alcohol swabs), storage, and place to discard syringes. Discuss the importance of not changing brands of insulin or syringes, selection and rotation of injection sites, and compliance with therapeutic regimen. Patients taking insulin detemir should be given the Patient Information circular for this product.
  • Explain to patient that this medication controls hyperglycemia but does not cure diabetes. Therapy is long term.
  • Instruct patient in proper testing of serum glucose and ketones. These tests should be closely monitored during periods of stress or illness and health care professional notified of significant changes.
  • Emphasize the importance of compliance with nutritional guidelines and regular exercise as directed by health care professional.
  • Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other Rx, OTC, herbal products, or alcohol.
  • Advise patient to notify health care professional of medication regimen prior to treatment or surgery.
  • Advise patient to notify health care professional if nausea, vomiting, or fever develops, if unable to eat regular diet, or if blood glucose levels are not controlled.
  • Instruct patient on signs and symptoms of hypoglycemia and hyperglycemia and what to do if they occur.
  • Patients with diabetes mellitus should carry a source of sugar (candy, glucose gel) and identification describing their disease and treatment regimen at all times.
  • Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding or planning to breastfeed.
  • Emphasize the importance of regular follow-up, especially during first few weeks of therapy.

Evaluation/Desired Outcomes

  • Control of blood glucose levels in diabetic patients without the appearance of hypoglycemic or hyperglycemic episodes.
Drug Guide, © 2015 Farlex and Partners

insulin detemir

A long-acting insulin analog whose structure differs from that of human insulin by the attachment of the fatty acid myristic acid at the end of the B chain in place of the amino acid threonine, used in the treatment of type 1 and type 2 diabetes.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive ?
TYPES AND NAMES OF DIABETES MEDICATIONS* CLASS BRAND NAMES Biguanides Glucophage, Fortamet GLP-1 receptor agonists Trulicity, Tanzeum, Bydureon, Victoza DPP-IV inhibitors Januvia, Onglyza, Nesina SGLT-2 inhibitors Invokana, Farxiga, Jardiance Sulfonylureas Amaryl, Glucotrol, DiaBeta, Glynase Insulin Tresiba, Toujeo, Afrezza, Levemir, Lantus Combination drugs Janumet, Jentadueto, Kombiglyze, Tradjenta, Kazano, Oseni * This chart provides examples of some, but not all, medications used to treat diabetes.
Other drugs include recently approved Symlin (Pramlintide Acetate), as an adjunct treatment in patients who use mealtime insulin therapy and who have failed to achieve desired glucose control despite optimal insulin therapy, and Levemir (Insulin Detemir) which is indicated for once or twice daily subcutaneous administration in the treatment of adult patients with Type 1 DM who require basal (long-acting) insulin for the control of hyperglycemia.
We do home blood glucose tests because his insulin dose requirement always changes." Silkie was switched from Humulin to longacting Levemir because he has been difficult to regulate.
5 December 2011 - Danish pharma major Novo Nordisk A/S (CPH:NOVO B) announced today positive results with its insulin analogues NovoMix 30, Levemir and NovoRapid, including better glucose control and improved rates of hypoglycaemia in patients with type 2 diabetes.
These include NPH (neutral protamine Hagedorn) or long-acting insulin analogues (insulin glargine (Lantus), insulin detemir (Levemir)).
Sales climbed 4% to 13.1 billion kroner, led by demand for Levemir and NovoRapid, which allows diabetics to control blood-sugar levels more precisely with fewer injections.
In either case, however, discard the product after four weeks, or six weeks for Levemir. Store insulin pens at room temperature after placing them in the delivery device.
The product, Levemir, will be commercially available by February or March.
Initially approved in Switzerland in March 2004, the agent is approved in 55 countries and currently marketed in 24 countries worldwide under the trade name of Levemir.
Levemir (insulin detemir [rDNA origin] injection, Novo Nordisk Inc.)
Novo Nordisk's FlexPen is the leading insulin delivery device in the United States and is used with Novo Nordisk's NovoLog Mix 70/30 (70% insulin aspart protamine suspension and 30% insulin aspart injection, (rDNA origin)), NovoLog (insulin aspart (rDNA origin) injection) and soon-to-be-launched Levemir (insulin detemir (rDNA origin) injection).