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Related to leukotrienes: Thromboxanes
Products of eicosanoid metabolism (usually, arachidonate) with several physiologic roles, such as mediation of inflammation and participation in allergic reactions; leukotrienes differ from the related prostaglandins and thromboxanes in that they do not have a central ring; so named because they were discovered in association with leukocytes and were initially determined to possess three conjugated double bonds; letters A-F identify the first six metabolites isolated, with subscript numbers to indicate the number of double bonds (for example, leukotriene C4).
Products of eicosanoid metabolism with physiologic roles in inflammation and allergic reactions.
leukotrienesPowerful chemical agents released by MAST CELLS, basophil cells and MACROPHAGES and involved in many allergic and other immunological reactions. Leukotrienes are derived from ARACHIDONIC ACID and cause CHEMOTAXIS and increase the leakiness of small blood vessels. In asthma they cause the narrowing of the air passages and the secretion of mucus. They can be inhibited by corticosteroid drugs.
A class of small molecules produced by cells in response to allergen exposure; they contribute to allergy and asthma symptoms.
Mentioned in: Leukotriene Inhibitors