leukotriene

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Related to Leukotriene antagonists: Leukotriene receptor antagonist

leukotriene

 [loo″ko-tri´ēn]
any of a group of compounds derived from unsaturated fatty acids, primarily arachidonic acid, that are extremely potent mediators of immediate hypersensitivity reactions and inflammation, producing smooth muscle contraction, especially bronchoconstriction, increased vascular permeability, and migration of leukocytes to areas of inflammation. Certain leukotrienes are collectively known as SRS-A (slow reacting substance of anaphylaxis), the name given to their potent bronchoconstrictor activity 30 years before their structure was elucidated; they also cause leakage of fluid and proteins from the microvasculature.

leukotriene

/leu·ko·tri·ene/ (-tri´ēn) any of a group of biologically active compounds derived from arachidonic acid that function as regulators of allergic and inflammatory reactions. They are identified by the letters A, B, C, D, and E, with subscript numerals indicating the number of double bonds in each molecule.

leukotriene

(lo͞o′kə-trī′ēn)
n.
Any of several lipid compounds that contain 20 carbon atoms, are related to prostaglandins, and mediate the inflammatory response.

leukotriene

substance formed from arachidonic acid which participates in inflammatory reactions, probably as leukotoxin. May act as a slow-reacting substance in anaphylaxis.
References in periodicals archive ?
Data Source: Two parallel, multicenter "pragmatic" trials to assess the real-world effectiveness of leukotriene antagonists compared with inhaled glucocorticoids as first-line treatment and compared with long-acting beta-agonists as add-on therapy for poorly controlled asthma.
The OTIS study compared perinatal outcomes for 96 women who took a leukotriene antagonist with perinatal outcomes for 122 women with asthma who took only short-acting [beta.
D] Do not commence leukotriene antagonists during pregnancy.
can cause significant adverse effects, such as profound sedation and urinary retention, and is used only for patients refractory to the more benign leukotriene antagonists and [H.
Currently the treatment of asthma/COPD favors the use of beta-2 agonists and inhaled corticosteroids, with leukotriene antagonists and anticholinergics being positioned as additional therapies in either pediatric or last-line patients.
To calculate the market size, the report considers the revenue generated from the sales of various class of drugs used in the treatment of asthma: - Bronchodilators - Leukotriene antagonists - Mast cell stabilizers - Immunosuppressants TechNavio's report, the Global Asthma Market 2014-2018, has been prepared based on an in-depth market analysis with inputs from industry experts.
The leukotriene antagonists are usually well tolerated and in some asthmatics can provide significant benefit.
All of them were using inhaled corticosteroids, but none used theophylline, nasal steroids, leukotriene antagonists, or [H.
Global asthma/COPD sales should grow to $23 billion by 2014, with inhaled corticosteroid/long-acting bronchodilator combinations set to be the leading class by value in 2014, followed by leukotriene antagonists, and anticholinergics.
Conte's second-line treatment approach includes alteration of diet, corticosteroids, the H2 antagonists cimetidine (Tagamet) or ranitidine (Zantac), doxepin, nifedipine, PUVA, warfarin, and leukotriene antagonists.