LTB4R

(redirected from Leukotriene B4 receptor)

LTB4R

A gene on chromosome 14q11.2-q12 that encodes a low-affinity G protein-coupled receptor for leukotrienes, including leukotriene B4. LTB4R mediates chemotaxis of granulocytes and macrophages by activating a phosphatidylinositol-calcium second messenger system. It is highly expressed in the heart, skeletal muscle and lymphoid tissue.
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Hashefi, "Stimulation of human neutrophils by 5-oxo-6,8,11,14eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor," Journal of Biological Chemistry, vol.
Medoff et al., "Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment," Nature Immunology, vol.
Effect of SC-41930, a potent leukotriene B4 receptor antagonist, in the guinea pig model of middle ear inflammation.