LTB4R

(redirected from Leukotriene B4 receptor)

LTB4R

A gene on chromosome 14q11.2-q12 that encodes a low-affinity G protein-coupled receptor for leukotrienes, including leukotriene B4. LTB4R mediates chemotaxis of granulocytes and macrophages by activating a phosphatidylinositol-calcium second messenger system. It is highly expressed in the heart, skeletal muscle and lymphoid tissue.
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Effect of SC-41930, a potent leukotriene B4 receptor antagonist, in the guinea pig model of middle ear inflammation.