leukocyte adhesion deficiency

(redirected from Leukocyte adhesion disorder)

leu·ko·cyte ad·he·sion de·fi·cien·cy (LAD),

an inherited disorder (autosomal recessive) in which there is a defective CD18 adherence complex that disturbs chemotaxis. It is characterized by recurrent bacterial pyogenic infections and impaired wound healing.

leukocyte adhesion deficiency (LAD)

an autosomal inherited disorder caused by a defective integrin molecule (CD18) that is important for cellular adhesion. This defect causes neutrophils to be immotile and unable to phagocytose. Patients with LAD have recurring bacterial infections and impaired wound healing, which may lead to necrosis and gangrene.

leu·ko·cyte ad·he·sion de·fi·cien·cy

(LAD) (lū'kō-sīt ad-hē'zhŭn dĕ-fish'ĕn-sē)
An inherited disorder in which there is a defective CD18 adherence complex that disturbs leukocyte chemotaxis. It is characterized by recurrent bacterial infections and impaired wound healing.

leukocyte adhesion deficiency

Abbreviation: LAD
A rare autosomal recessive disorder in which white blood cells are unable to migrate out of blood vessels in response to infection. It often presents in early childhood with severe periodontal disease, premature loss of teeth, and recurrent infections.
See also: deficiency