leukocidin

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leukocidin

 [loo″ko-si´din]
1. a substance toxic to leukocytes, killing the cells with or without lysis.
2. a type of exotoxin produced by pathogenic bacteria such as staphylococci or streptococci; it destroys leukocytes and may also damage monocytes and macrophages.

leu·ko·ci·din

(lū'kō-sī'din, lū-kō-sī'din),
A heat-labile substance that is elaborated by many strains of Staphylococcus aureus, Streptococcus pyogenes, and pneumococci and manifests a destructive action on leukocytes, with or without lysis of the cells.
[leukocyte + L. caedo, to kill]

leukocidin

/leu·ko·ci·din/ (-si´din) a substance produced by some pathogenic bacteria that is toxic to polymorphonuclear leukocytes (neutrophils).

leukocidin

(1) An antibody which lyses white cells following complement fixation.
(2) A pore-forming cytotoxin produced by certain bacteria.

leu·ko·ci·din

(lū'kō-sī'din)
A heat-labile substance that is elaborated by many strains of Staphylococcus aureus, Streptococcus pyogenes, and pneumococci; manifests a destructive action on leukocytes, with or without lysis of the cells.
Synonym(s): leucocidin.
[leukocyte + L. caedo, to kill]

leukocidin

a substance produced by some pathogenic bacteria that is toxic to polymorphonuclear leukocytes (neutrophils).
References in periodicals archive ?
Community-acquired methicillin- resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence.
Identification of staphylococcal Panton-Valentine leukocidin as a potent dermonecrotic toxin.
Community-acquired methicillin-resistant Staphylococcus aureus isolated in Switzerland contains the Panton-Valentine leukocidin or exfoliative toxin genes.
Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotizing pneumonia in young immunocompetent patients.
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia.
cephalosporins such as cefepime or quinolones, which eradicate susceptible gram-positive, gram-negative, and anaerobic flora) Community-acquired No specific antibiotic usage pattern has been (CA) associated with CA- MRSA (with the possible exception of amoxicillin use in children) (8) Type of MRSA Resistance genes Hospital-acquired Contains distinct SCCmec types, plasmids (HA) encoding resistance to various antibiotics, as well as heavy metal resistance elements Community-acquired Contains SCCmec type IV (CA) Type of MRSA Toxins Hospital-acquired Characteristically lacks the toxin genes (HA) Community-acquired May possess staphylococcal enterotoxins B and C, (CA) toxic shock syndrome toxin-1, and Panton-Valentine leukocidin Table 3.
designation [6]), but also that of the locus for the Panton-Valentine leukocidin (PVL).
In addition, 112 isolates harbored the related lukE-lukD genes of another leukocidin frequently recovered from patients with all types of staphylococcal infections (3).
In addition, unlike the PVL genes, lukE-lukD leukocidin genes were found in most HAMRSA (95%) as well as in CA-MRSA.