leukocidin

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leukocidin

[loo″ko-si´din]

1. a substance toxic to leukocytes, killing the cells with or without lysis.

2. a type of exotoxin produced by pathogenic bacteria such as staphylococci or streptococci; it destroys leukocytes and may also damage monocytes and macrophages.

leu·ko·ci·din

(lū'kō-sī'din, lū-kō-sī'din),

A heat-labile substance that is elaborated by many strains of Staphylococcus aureus, Streptococcus pyogenes, and pneumococci and manifests a destructive action on leukocytes, with or without lysis of the cells.

[leukocyte + L. caedo, to kill]

Farlex Partner Medical Dictionary © Farlex 2012

leukocidin

(1) An antibody which lyses white cells following complement fixation.
(2) A pore-forming cytotoxin produced by certain bacteria.

leu·ko·ci·din

(lū'kō-sī'din)

A heat-labile substance that is elaborated by many strains of Staphylococcus aureus, Streptococcus pyogenes, and pneumococci; manifests a destructive action on leukocytes, with or without lysis of the cells.
Synonym(s): leucocidin.

[leukocyte + L. caedo, to kill]

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

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References in periodicals archive ?

Panton-Valentine leukocidin rises the pathogenicity of S.

Mohapatra, "High Prevalence of Panton-Valentine leukocidin (PVL) genes in nosocomial-acquired staphylococcus aureus isolated from tertiary care hospitals in Nepal," BioMed Research International, vol.

Prevalence of Panton-Valentine Leukocidin Gene among Community Acquired Staphylococcus aureus: A Real-Time PCR Study

The frequent recovery of staphylococcal isolates that produce leukocidal toxins from patients with deep skin soft tissue infections, particularly furunculosis, cutaneous abscesses, severe necrotizing pneumonia, and even UTIs, suggests that the Panton-Valentine leukocidin (PVL) is a virulence factor that has a major role in pathogenicity [7-14].

Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis.

Meticillin-resistant Staphylococcus aureus isolated from Iranian hospitals: virulence factors and antibiotic resistance properties

[alpha]-Hemolysin, [gamma]-Hemolysin, and Leukocidins from Staphylococcus aureus

Although most clinical isolates produce the PFTs a-hemolysin, bicomponent [gamma]-hemolysins, and bicomponent leukocidins, none of these toxins was found to be a necessary and sufficient virulence determinant of neonatal sepsis.

Role of pore-forming toxins in neonatal sepsis

Otto's group to be a candidate factor for increased virulence, suggesting it to be more important than Panton-Valentine leukocidin (PVL).

MRSA is a superbug: caution advised

Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes.

Antimicrobial susceptibility, virulence determinant carriage and molecular characteristics of Staphylococcus aureus isolates associated with skin and soft tissue infections

The CA-MRSA strains shared a type IV SCCmec cassette and the Panton-Valentine leukocidin locus, whereas the distribution of the other toxin genes was quite specific to the strains from each continent.

designation [6]), but also that of the locus for the Panton-Valentine leukocidin (PVL).

Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. (Research)

Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?

Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia.

Pediatric pneumonia death caused by community-acquired methicillin-resistant Staphylococcus aureus, Japan