leukocyte adhesion deficiency

(redirected from Leucocyte adhesion deficiency)

leu·ko·cyte ad·he·sion de·fi·cien·cy (LAD),

an inherited disorder (autosomal recessive) in which there is a defective CD18 adherence complex that disturbs chemotaxis. It is characterized by recurrent bacterial pyogenic infections and impaired wound healing.

leu·ko·cyte ad·he·sion de·fi·cien·cy

(LAD) (lū'kō-sīt ad-hē'zhŭn dĕ-fish'ĕn-sē)
An inherited disorder in which there is a defective CD18 adherence complex that disturbs leukocyte chemotaxis. It is characterized by recurrent bacterial infections and impaired wound healing.

leukocyte adhesion deficiency

Abbreviation: LAD
A rare autosomal recessive disorder in which white blood cells are unable to migrate out of blood vessels in response to infection. It often presents in early childhood with severe periodontal disease, premature loss of teeth, and recurrent infections.
See also: deficiency
References in periodicals archive ?
Can occur in children and adolescents which include Papillon-Lefevre syndrome, cyclic neutropenia, agranulocytosis, Down syndrome, hypophosphatasia and leucocyte adhesion deficiency. Defects in neutrophil and immune cell function may play a role in increased susceptibility to periodontitis and other infection.